Results 151 to 160 of about 765,759 (204)

Simultaneous Inhibition of MDM2 and XIAP by MX69 Induced Cell Cycle Arrest and Apoptosis in HUH7 and Hep3B Cell Lines. [PDF]

Curr Issues Mol Biol
Ağca CA.
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Paeonol inhibits the development of oral squamous cell carcinoma through the PI3K/AKT signaling pathway. [PDF]

Front Cell Dev Biol
Liu C, Mou X, Liu J, Wu Y, Han J, Li R, Gao Y, Liu Y.   +7 more
europepmc   +1 more source

Platelet aging and desialylation increase apoptotic priming and BCL-X_L dependence. [PDF]

Cell Death Dis
Grozovsky R, Fraser CS, Qin X, Spetz J, Sarosiek KA.   +4 more
europepmc   +1 more source

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Lysine Covalent Antagonists of Melanoma Inhibitors of Apoptosis Protein

Journal of Medicinal Chemistry, 2021
We have recently reported on Lys-covalent agents that, based on aryl-sulfonyl fluorides, were designed to target binding site Lys 311 in the X-linked inhibitor of apoptosis protein (XIAP). Similar to XIAP, melanoma-IAP (ML-IAP), a less well-characterized IAP family protein, also presents a lysine residue (Lys 135), which is in a position equivalent to ...
Parima Udompholkul, Carlo Baggio, Luca Gambini, Giulia Alboreggia, Maurizio Pellecchia   +4 more
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Survivin: A Bifunctional Inhibitor of Apoptosis Protein

Veterinary Pathology, 2004
Survivin is a recently discovered protein belonging to the inhibitor of apoptosis (IAP) gene family. IAP molecules are characterized by both the presence of a zinc-binding fold termed the baculoviral IAP repeat and the ability to suppress apoptosis. In addition to inhibiting apoptosis, survivin is essential for proper cell division.
M E, Johnson, E W, Howerth
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Inhibitor of apoptosis proteins (IAPs) as regulatory factors of hepatic apoptosis

Cellular Signalling, 2013
IAPs are a group of regulatory proteins that are structurally related. Their conserved homologues have been identified in various organisms. In human, eight IAP members have been recognized based on baculoviral IAP repeat (BIR) domains. IAPs are key regulators of apoptosis, cytokinesis and signal transduction. The antiapoptotic property of IAPs depends
Kewei, Wang, Bingliang, Lin
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Targeting Inhibitor of Apoptosis Proteins for Therapeutic Intervention

Future Medicinal Chemistry, 2009
The inhibitors of apoptosis (IAP) proteins have emerged over the last decade as important targets for therapeutic intervention in human malignancies. Overexpression of IAPs has been implicated in cell survival and resistance against stress-induced apoptosis brought on by radiation and/or chemotherapeutics (currently the standard-of-care in a variety of
Chudi, Ndubaku, Frederick, Cohen, Eugene, Varfolomeev, Domagoj, Vucic   +3 more
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