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Inhibitors of Apoptosis Proteins
2003The preceding decade has witnessed a genuine revolution in our understanding of the regulation of cell homeostasis in health and disease. Apoptosis has emerged as the fundamental mechanism of cell loss in most, if not all, genetic disorders and injury states, and has also resulted in a fundamental change in our understanding of the molecular basis of ...
Peter Liston +2 more
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Inhibitor of apoptosis protein survivin regulates vascular injury
Nature Medicine, 2002Survivin (also termed Birc5) belongs to the family of genes known as inhibitors of apoptosis, and it has been implicated in both prevention of cell death and control of mitosis. The survivin pathway is exploited in cancer, but its potential role in vascular injury is unknown.
Olivier P, Blanc-Brude +5 more
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Targeted Nanoswitchable Inhibitors of Protein–Protein Interactions Involved in Apoptosis
ChemMedChem, 2018AbstractProgress in drug delivery is hampered by a lack of efficient strategies to target drugs with high specificity and precise spatiotemporal regulation. The remote control of nanoparticles and drugs with light allows regulation of their action site and dosage.
Laura Nevola +6 more
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Inhibitor of apoptosis proteins (IAPS)
2001Abstract IAP family proteins are conserved throughout animal evolution and can block apoptosis when expressed in cells derived from multiple species often suppressing apoptosis across species barriers (Reviewed in Clem and Duckett, 1998 ). Thus, while the details of their regulation may vary, these proteins evidently target a common mechanism ...
Quinn L. Deveraux, John C. Reed
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Inhibitor of apoptosis proteins in Drosophila: gatekeepers of death
Apoptosis, 2009Regulation of apoptosis is crucial to ensure cellular viability, and failure to do so is linked to several human pathologies. The apoptotic cell death programme culminates in the activation of caspases, a family of highly specific cysteine proteases essential for the destruction of the cell.
Mariam, Orme, Pascal, Meier
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Journal of Medicinal Chemistry, 2011
We report a second example of a general reaction screening approach to discover low molecular weight inhibitors of protein protein interactions. On the basis of the known pharmacophore model of SMAC mimetics, we predicted several inhibitors based on four different multicomponent reactions. The predicted inhibitors were subsequently synthesized, tested,
Ilaria, Monfardini +5 more
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We report a second example of a general reaction screening approach to discover low molecular weight inhibitors of protein protein interactions. On the basis of the known pharmacophore model of SMAC mimetics, we predicted several inhibitors based on four different multicomponent reactions. The predicted inhibitors were subsequently synthesized, tested,
Ilaria, Monfardini +5 more
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Inhibitor of Apoptosis Proteins and Caspases
2007Inhibitors of apoptosis proteins (IAPs) were first identified as insect viral proteins that block host cell apoptosis. Cellular homologs bearing the characteristic baculoviral IAP repeat (BIR) domain have now been found in all metazoans and have more diverse functions than their name suggests.
Jai Y. Yu, John Silke, Paul G. Ekert
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Inhibitor of apoptosis proteins in human health and disease
Genes & Immunity, 2019The inhibitor of apoptosis proteins (IAPs) are best known for their ability to regulate cell survival and death processes. However, in addition to cell death, IAPs also act as innate immune sensors and modulate multiple pathways, such as autophagy and cell division.
Matous, Hrdinka, Monica, Yabal
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Targeting melanoma inhibitor of apoptosis protein with cancer immunotherapy
Apoptosis, 2004Aberrantly expressed or mutated proteins in cancer cells evoke immune recognition, but host reactions are usually insufficient to prevent disease progression. Vaccination with irradiated tumor cells engineered to secrete granulocyte-macrophage colony stimulating factor (GM-CSF) augments host immunity through improved tumor antigen presentation by ...
J C, Schmollinger, G, Dranoff
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Inhibitors of apoptosis proteins in prostate cancer cell lines
The Prostate, 2002AbstractBACKGROUNDThe caspases are the central executioners of apoptosis. The inhibitors of apoptosis proteins (IAPs) are a family of recently described caspase inhibitors. We hypothesised that tumor resistance to apoptosis could be due in part to IAP expression.METHODSThe expression of NAIP, cIAP‐1, cIAP‐2, XIAP, and survivin was investigated in the ...
Kevin R, McEleny +4 more
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