Results 171 to 180 of about 765,759 (204)
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Structure-based design and synthesis of tricyclic IAP (Inhibitors of Apoptosis Proteins) inhibitors
Bioorganic & Medicinal Chemistry Letters, 2014The design and synthesis of a series of novel tricyclic IAP inhibitors is reported. Rapid assembly of the core tricycle involved two key steps: Rh-catalyzed hydrogenation of an unsaturated bicyclic ring system and a Ru-catalyzed ring closing alkene metathesis reaction.
Alexander W, Hird +9 more
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Targeting apoptosis in prostate cancer: focus on caspases and inhibitors of apoptosis proteins
BJU International, 2005Androgens are critical to the growth and differentiation of prostate epithelial cells. Removal of androgen normally results in apoptosis, but androgen‐independent tumours have developed mechanisms that allow cells to survive the loss of androgen. The caspases are central mediators of cell death.
R William G, Watson, John M, Fitzpatrick
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Immunology & Cell Biology, 2017
Understanding how inhibitor of apoptosis proteins (IAPs) regulate apoptosis and necroptosis has been fast‐forwarded by the use of Smac mimetics (SMs) to deplete or inhibit the IAPs, specifically cIAP1, cIAP2 and XIAP. The loss or inhibition of cIAP1, cIAP2 and XIAP causes the majority of cells to be sensitized to death receptor induced cell death, such
Vasilikos, Lazaros +3 more
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Understanding how inhibitor of apoptosis proteins (IAPs) regulate apoptosis and necroptosis has been fast‐forwarded by the use of Smac mimetics (SMs) to deplete or inhibit the IAPs, specifically cIAP1, cIAP2 and XIAP. The loss or inhibition of cIAP1, cIAP2 and XIAP causes the majority of cells to be sensitized to death receptor induced cell death, such
Vasilikos, Lazaros +3 more
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Targeting the Inhibitor of Apoptosis Protein BIR3 Binding Domains
Pharmaceutical Patent Analyst, 2014The Inhibitor of Apoptosis Proteins (IAPs) play a critical role in the regulation of cellular apoptosis and cytokine signaling. IAP family members include XIAP, cIAP1, cIAP2, NAIP, survivin, Apollon/Bruce, ML-IAP/livin and TIAP. The IAPs have been targeted using both antisense oligonucleotides and small molecule inhibitors.
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Inhibitor of apoptosis proteins as targets for anticancer therapy
Expert Review of Anticancer Therapy, 2007Cell death by apoptosis plays a critical role in regulating the subtle balance between cell death and proliferation to maintain tissue homeostasis. Accordingly, tipping the balance in either direction may cause human disease. Too little cell death may promote tumor formation and progression.
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Targeting Inhibitor of Apoptosis Proteins (IAPs) for Cancer Therapy
Anti-Cancer Agents in Medicinal Chemistry, 2008Since cell death by apoptosis plays a key role in the regulation of tissue homeostasis, dysregulation of the cell's intrinsic death program may foster tumor formation and progression. "Inhibitor of apoptosis proteins" (IAPs) block apoptosis at the core of the apoptotic machinery by inhibiting effector caspases.
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Ubiquitination mediated by inhibitor of apoptosis proteins.
Methods in enzymology, 2008Inhibitor of apoptosis (IAP) proteins are a family of evolutionarily conserved proteins that regulate apoptosis as well as other cellular processes. The functions of many IAPs are defined by their RING domains, which possess E3 ubiquitin ligase activity and promote proteasomal degradation of an increasing number of target proteins.
Sun-Mi, Park +3 more
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Research progress on Livin protein: an inhibitor of apoptosis
Molecular and Cellular Biochemistry, 2011Livin is a member of the inhibitors of apoptosis (IAP) family, which plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Abnormal Livin expression is sometimes detected during the process of cancer formation and/or progression.
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