Results 21 to 30 of about 765,759 (204)

Interaction of DNA-lesions induced by sodium fluoride and radiation and its influence in apoptotic induction in cancer cell lines

Toxicology Reports, 2015
Fluoride is an essential trace element but also an environmental contaminant with major sources of exposure being drinking water, food and pesticides. Previous studies showed that sodium fluoride (NaF) at 5 mM or more is required to induce apoptosis and ...
Santosh Podder, Nitin Ghoshal, Atanu Banerjee, Buddha Ganguly, Ravi Upadhyay, Anupam Chatterjee   +5 more
doaj   +1 more source

How to target apoptosis signaling pathways for the treatment of pediatric cancers [PDF]

, 2013
Apoptosis represents one of the most important forms of cell death in higher organisms and is typically dysregulated in human cancers, including pediatric tumors.
Fulda, Simone
core   +2 more sources

Inhibitor of apoptosis proteins as E3 ligases for ubiquitin and NEDD8

Biomolecular Concepts, 2013
The inhibitors of apoptosis proteins (IAPs) are endogenous inhibitors for apoptosis. Apoptosis is carried out by caspases, which are the family of cystein proteases. IAPs regulate caspases through two conserved regions, the baculovirus IAP repeats (BIRs)
Kamada Shinji
doaj   +1 more source

GSK-J4 induces cell cycle arrest and apoptosis via ER stress and the synergism between GSK-J4 and decitabine in acute myeloid leukemia KG-1a cells

Cancer Cell International, 2020
Background GSK-J4 is the inhibitor of H3K27me3 demethylase. Recent studies demonstrated that GSK-J4 could affect the proliferation and apoptosis of a variety of cancer cells.
Xuan Chu, Liang Zhong, Lihua Yu, Ling Xiong, Jian Li, Wenran Dan, Jiao Ye, Chen Liu, Xu Luo, Beizhong Liu   +9 more
doaj   +1 more source

Interactions between Endoplasmic Reticulum Stress and Autophagy: Implications for Apoptosis and Neuroplasticity-Related Proteins in Palmitic Acid-Treated Prefrontal Cells

Neural Plasticity, 2021
Lipotoxicity of palmitic acid (PA) or high-fat diets has been reported to increase endoplasmic reticulum (ER) stress and autophagy in peripheral tissue as well as apoptotic cell death. It also can lead to an AD-like pathological pattern.
Xiangli Xue, Feng Li, Ming Cai, Jingyun Hu, Qian Wang, Shujie Lou   +5 more
doaj   +1 more source

Small inhibitor of Bcl-2, HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating Bcl-2 family members in MDA-MB-231 breast cancer cells [PDF]

, 2010
Inhibition or downregulation of Bcl-2 represents a new therapeutic approach to by-pass chemoresistance in cancer cells. Therefore, we explored the potential of this approach in breast cancer cells.
A Letai, AK Zimmermann, Cagri Bodur, D Moon, D Tian, Dilek Telci, DJ Stewart, Elif Damla Arisan, F Manero, FA Sinicrope, Huveyda Basaga, IJ Enyedy, J An, J Chen, J Skommer, J Yu, JC Reed, JD Lickliter, JI Okani, JL Wang, JL Wang, L Chen, L Ming, L Oliver, M Milella, Ozgur Kutuk, RK Srivastava, SW Lowe, Tugsan Tezil, X Pei, X Wang, XY Pei, Y Ling, Y Su, Z Liu   +34 more
core   +1 more source

p97 inhibitor EerⅠ induces apoptosis and ferroptosis of gastric cancer cell line AGS [PDF]

Jichu yixue yu linchuang
Objective To investigate the molecular mechanism of the induction of gastric cancer cell line AGS death by p97 inhibitor eeyarestatinⅠ (EerⅠ). Methods AGS cells were treated with EerⅠ.
LI Wenhua, WANG Runlin, KANG Qianpeng, HUANG Mei, GUO Zhengguang, ZHANG Chunlin, HUANG Yongsheng
doaj   +1 more source

Inhibitor of Apoptosis Proteins: Promising Targets for Cancer Therapy [PDF]

Journal of Carcinogenesis & Mutagenesis, 2013
Cancer is a disease in which normal physiological processes are imbalanced, leading to tumour formation, metastasis and eventually death. Recent biological advances have led to the advent of targeted therapies to complement traditional chemotherapy and radiotherapy.
Owens, TW, Gilmore, AP, Streuli, CH, Foster, FM   +3 more
openaire   +2 more sources

Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1 [PDF]

, 2020
Cancer therapeutics: Extending a drug's reach A new drug that blocks heat shock proteins (HSPs), helper proteins that are co-opted by cancer cells to promote tumor growth, shows promise for cancer treatment.
Chae, Young Chan, Hong, Jun-Hee, Hu, Sung, Kang, Byoung Heon, Kim, So Yeon, Lee, Ji-Eun, Nam, Dougu, Park, Hye-Kyung, Park, Jong Bae, Yoon, Nam Gu, Yoon, Sora   +10 more
core   +1 more source

Structural and Functional Insight into Canarypox Virus CNP058 Mediated Regulation of Apoptosis

Viruses, 2017
Programmed cell death or apoptosis is an important component of host defense systems against viral infection. The B-cell lymphoma 2 (Bcl-2) proteins family is the main arbiter of mitochondrially mediated apoptosis, and viruses have evolved sequence and ...
Mohd Ishtiaq Anasir, Amy A. Baxter, Ivan K. H. Poon, Mark D. Hulett, Marc Kvansakul   +4 more
doaj   +1 more source