Results 51 to 60 of about 765,759 (204)
Targeting ATM pathway for therapeutic intervention in cancer [PDF]
, 2012 The Ataxia Telangiectasia Mutated gene encodes the ATM protein, a key element in the DNA damage response (DDR) signalling pathway responsible for maintaining genomic integrity within the cell.
Chakarov, Stoyan +4 more
core +3 more sources
Cancer Management and Research, 2021 Yirong Wang,1,* Lei Yang,2,* Yan Yang,3 Yulin Li4 1Department of Radiotherapy, Yantaishan Hospital, Yantai 264000, People’s Republic of China; 2Department of Tuberculosis, Shandong Provincial Chest Hospital, Jinan 250013, People’s Republic of
Wang Y, Yang L, Yang Y, Li Y
doaj
Frontiers in Oncology, 2014 Defects in apoptosis regulation are one main cause of cancer development and may result from overexpression of anti-apoptotic proteins such as Inhibitor of Apoptosis Proteins (IAPs).
Petra eObexer, Michael J. Ausserlechner
doaj +1 more source
Experimental Biology and Medicine, 2011 We report here a series of new inhibitors of the X-linked inhibitor of apoptosis protein (XIAP protein) based on the SMAC-tetrapeptide AVPI. The structural novelty of these molecules is the presence of the proline mimetic exo-2-azabicyclo[2.2.1]heptane-3-carboxylic acid, leading to analogs with similar activity to the natural ligand peptide.
Qi, Hu +9 more
openaire +2 more sources
The Drosophila Inhibitor of Apoptosis (IAP) DIAP2 Is Dispensable for Cell Survival, Required for the Innate Immune Response to Gram-negative Bacterial Infection, and Can Be Negatively Regulated by the Reaper/Hid/Grim Family of IAP-binding Apoptosis Inducers [PDF]
, 2007 Many inhibitor of apoptosis (IAP) family proteins inhibit apoptosis. IAPs contain N-terminal baculovirus IAP repeat domains and a C-terminal RING ubiquitin ligase domain.
Chen, Chun Hong +8 more
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Frontiers in Molecular Biosciences, 2021 Benign esophageal strictures (BESs) frequently results from esophageal fibrosis. The transformation of fibroblasts into fibrocyte is an important cause of fibrosis. The treatment of fibrosis is challenging.
Yin Zhang +17 more
doaj +1 more source
The Drosophila DIAP1 protein is required to prevent accumulation of a continuously generated, processed form of the apical caspase DRONC [PDF]
, 2002 Although loss of the inhibitor of apoptosis (LAP) protein DIAP1 has been shown to result in caspase activation and spontaneous cell death in Drosophila cells and embryos, the point at which DIAP1 normally functions to inhibit caspase activation is ...
Clem, Rollie J. +2 more
core +1 more source
A B-Cell Superantigen Induces the Apoptosis of Murine and Human Malignant B Cells. [PDF]
PLoS ONE, 2016 B-cell superantigens (Sags) bind to conserved sites of the VH or VL regions of immunoglobulin molecules outside their complementarity-determining regions causing the apoptosis of normal cognate B cells.
Daniela Lorenzo +5 more
doaj +1 more source
Could Upregulated Hsp70 Protein Compensate for the Hsp90-Silence-Induced Cell Death in Glioma Cells? [PDF]
, 2014 The molecular chaperone heat shock protein 90 alpha (Hsp90α) has been recognized in various tumours including glioma. This pilot study using a proteomic approach analyses the downstream effects of Hsp90 inhibition using 17-allylamino-17 ...
Khan, Zarine Jamsher +3 more
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Data in Brief, 2016 Content of particular proteins indicating cellular injury due to apoptosis and necrosis has been investigated in ischemic/reperfused (IR) hearts and ischemic/reperfused hearts treated with CaMKII inhibitor and/or AT1 receptor inhibitor. This data article
Tomas Rajtik +9 more
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