The Analysis of Apoptosis in Ameloblastoma: Evaluation of Bcl-2, Bcl-X, Bax, Bak
Journal of Dentistry Indonesia, 2015 The apoptotic behavior of ameloblastomas was studied using antibodies against the apoptosis related proteins, Bcl-2, Bcl-X, Bax and Bak. Most of the outer layer cells were predominantly stained by the antimodulating proteins, Bax and Bak. Among the Bcl-2
Ferry Sandra +5 more
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Foods, 2022 This study was designed to explore the beneficial effect and mechanism of Ganoderma atrum (G. atrum) polysaccharide (PSG-1) on acrolein-induced IEC-6 cells.
Yudan Wang +9 more
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Fragment-Based Design of Small Molecule X-Linked Inhibitor of Apoptosis Protein Inhibitors [PDF]
Journal of Medicinal Chemistry, 2008 We report on a general structure- and NMR-based approach to derive druglike small molecule inhibitors of protein-protein interactions in a rapid and efficient manner. We demonstrate the utility of the approach by deriving novel and effective SMAC mimetics targeting the antiapoptotic protein X-linked inhibitor of apoptosis protein (XIAP).
Jui-Wen, Huang +11 more
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BH3 mimetic ABT-737 sensitizes colorectal cancer cells to ixazomib through MCL-1 downregulation and autophagy inhibition. [PDF]
, 2016 The proteasome inhibitor MLN9708 is an orally administered drug that is hydrolyzed into its active form, MLN2238 (ixazomib). Compared with Bortezomib, MLN2238 has a shorter proteasome dissociation half-life and a lower incidence and severity of ...
Barkhouse, Darryll +7 more
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Targeting apoptotic machinery as approach for anticancer therapy: Smac mimetics as anticancer agents
Future Journal of Pharmaceutical Sciences, 2015 Apoptosis is a chief regulator of cellular homeostasis. Impairment of apoptotic machinery is a main characteristic of several diseases such as cancer, where the evasion of apoptosis is a cardinal hallmark of cancer. Apoptosis is regulated by contribution
Nevine M.Y. Elsayed +3 more
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ATM in focus:a damage sensor and cancer target [PDF]
, 2012 The ability of a cell to conserve and maintain its native DNA sequence is fundamental for the survival and normal functioning of the whole organism and protection from cancer development.
Khalil, Hilal S. +2 more
core +4 more sources
Scientific ReportsProtein ubiquitination is a dynamic and reversible process involved in gene transcription, protein metabolism, and cellular apoptosis. Ubiquitin specific proteases (USPs), as the largest family of deubiquitinating enzymes, are able to remove the ...
Xiang Li +10 more
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The Effect of Podophyllotoxin as an Inducer of Apoptosis Using Molecular Docking Method
Armaghane Danesh Bimonthly Journal, 2021 Background and aim: Podophyllotoxin is used as one of the main treatments for genital warts. It is a precursor of etoposide and teniposide, which is used in the treatment of various cancers.
MS Talebianpoor +2 more
doaj
Adenovirus‐Mediated Gene Transfer of Inhibitors of Apoptosis Proteins Delays Apoptosis in Cerebellar Granule Neurons [PDF]
Journal of Neurochemistry, 1999 Abstract : The inhibitor of apoptosis (IAP) family of anti‐apoptotic genes, originally discovered in baculovirus, exists in animals ranging from insects to humans. Here, we investigated the ability of IAPs to suppress cell death in both a neuronal model of apoptosis and excitotoxicity.
Simons, Mikael +10 more
openaire +3 more sources
The endogenous caspase-8 inhibitor c-FLIPL regulates ER morphology and crosstalk with mitochondria [PDF]
, 2014 Components of the death receptors-mediated pathways like caspase-8 have been identified in complexes at intracellular membranes to spatially restrict the processing of local targets.
A Filippini +53 more
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