Results 91 to 100 of about 5,057,415 (322)
Healthy nutrition barriers: perception of adults male
Payesh, 2012 Objective (s): Existing data show a considerable prevalence of non communicable diseases risk factors and their rising trend in our country. Unhealthy nutrition is an important underlying factor for mentioned diseases.
Fahimeh Ramezani Tehrani +4 more
doaj
Numeric modeling of fire suppression by organophosphorous inhibitors [PDF]
arXiv, 2008 Numerical calculations of the effect of organophosphorous inhibitor (CF3CH2O)3P and its mixtures with carbon dioxide on propane flames are carried out using the three dimensional Reynolds-averaged Navier-Stokes (RANS) equations in the low Mach number approximation. The k-e model of turbulence, the EDC combustion model and the weighted-sum-of-gray-gases
arxiv
Drug design principles from electric field calculations: understanding SARS-CoV-2 main protease interaction with X77 non-covalent inhibitor [PDF]
arXiv, 2020 Fast and effective drug discovery processes rely on rational drug design to circumvent the tedious and expensive trial and error approach. However, accurate predictions of new remedies, which are often enzyme inhibitors, require a clear understanding of the nature and function of the key players governing the interaction between the drug candidate and ...
arxiv
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
In Silico Design, Extended Molecular Dynamic Simulations and Binding Energy Calculations for a New Series of Dually Acting Inhibitors against EGFR and HER2 [PDF]
arXiv, 2013 Starting from the lead structure we have identified in our previous works, we are extending our insight understanding of its potential inhibitory effect against both EGFR and HER2 receptors. Herein and using extended molecular dynamic simulations and different scoring techniques, we are providing plausible explanations for the observed inhibitory ...
arxiv
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum
FEBS Letters, EarlyView.In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti +3 more
wiley +1 more source
Терапевтический архив, 2003 Aim. To study the activity of angiotensin-converting enzyme (ACE) in patients with pneumonia and chronic obstructive lung diseases (COLD). Material and Methods. Sixty nine patients with pneumonia and 77 with COLD were examined. The activity of ACE in the
B Yu Altshuler +8 more
doaj
Advanced Science, 2020 The Rho family GTPases are crucial drivers of tumor growth and metastasis. However, it is difficult to develop GTPases inhibitors due to a lack of well‐characterized binding pockets for compounds.
Zhongya Sun +25 more
doaj +1 more source
A framework for generalized group testing with inhibitors and its potential application in neuroscience [PDF]
arXiv, 2018 The main goal of group testing with inhibitors (GTI) is to efficiently identify a small number of defective items and inhibitor items in a large set of items. A test on a subset of items is positive if the subset satisfies some specific properties. Inhibitor items cancel the effects of defective items, which often make the outcome of a test containing ...
arxiv
A comprehensive review on tyrosinase inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 Tyrosinase is a multi-copper enzyme which is widely distributed in different organisms and plays an important role in the melanogenesis and enzymatic browning.
S. Zolghadri +6 more
semanticscholar +1 more source