Results 101 to 110 of about 2,437,359 (310)
Differential effects of low molecular weight inhibitors on the conformation and the immunologic function of the adhesion receptor LFA-1 [PDF]
, 2004 Previous studies of our group 1,2 and by others 3 on the isolated ligand binding domain of LFA-1 (αL I domain) have suggested that some LFA-1 inhibitors act allosterically while other inhibitors were proposed to competitively block the LFA- 1/ligand ...
Welzenbach, Karl Albert
core +1 more source
Short Peptides with Uncleavable Peptide Bond Mimetics as Photoactivatable Caspase-3 Inhibitors
Molecules, 2019 Chemical probes that covalently interact with proteases have found increasing use for the study of protease function and localization. The design and synthesis of such probes is still a bottleneck, as the strategies to target different families are ...
Tim Van Kersavond +5 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Drugging the Small GTPase Pathways in Cancer Treatment: Promises and Challenges
Cells, 2019 Small GTPases are a family of low molecular weight GTP-hydrolyzing enzymes that cycle between an inactive state when bound to GDP and an active state when associated to GTP.
Néstor Prieto-Dominguez +2 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Molecules, 2019 Dipeptidyl peptidase-IV (DPP-IV) rapidly breaks down the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP).
Azizullo Musoev +3 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Rational Design of Cholinesterase Inhibitors
, 2000 With the collaboration of the most distinguished scholars in this field Professor Giacobini has put together a publication which will convey present knowledge in the field of molecular biology and genetics, biochemistry, cell biology, pharmacology and ...
FILOCAMO, Luigi, BRUFANI, Mario
core
Application of polymer composites and nanocomposites as corrosion inhibitors [PDF]
, 2016 Corrosion commonly defined as the deterioration of a material (usually a metal) or its properties because of a reaction with its environment is a global problem.
Umoren, Saviour A., Solomon, Moses M.
core +1 more source