Frontiers in Immunology, 2020 The endoplasmic reticulum (ER) is an organelle equipped with mechanisms for proper protein folding, trafficking, and degradation to maintain protein homeostasis in the secretory pathway.
Anqi Li +6 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Neprilysin inhibitors for the treatement of heart failure
, 2023 Neprilysin inhibitors, such as sacubitril/valsartan, are a class of drugs used in the treatment of heart failure with reduced ejection fraction (HFrEF). They work by inhibiting the enzyme neprilysin, which increases the levels of beneficial peptides like
Abo Asalh, Majd
core
Development of novel, potent and selective small molecular weight PI3K/mTOR inhibitors for the treatment of cancer [PDF]
, 2011 The phosphoinositide 3-kinases (PI3Ks) belong to a family of lipid kinases, which are implicated in signal transduction pathways and modulation of fundamental cellular activities such as cell growth, proliferation, differentiation, motility, survival and
Cmiljanović, Nataša
core +1 more source
Short Peptides with Uncleavable Peptide Bond Mimetics as Photoactivatable Caspase-3 Inhibitors
Molecules, 2019 Chemical probes that covalently interact with proteases have found increasing use for the study of protease function and localization. The design and synthesis of such probes is still a bottleneck, as the strategies to target different families are ...
Tim Van Kersavond +5 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Pharmacology of Proteasome inhibitors
, 2020 A review on the pharmacology of proteasome inhibitors. It focuses on its pharmacokinetics and its pharmacodynamics, mechanism of action and its effect on the therapy of various cancers especially in multiple myeloma and solid tumors.általános ...
Omalu, Chinedu Stephen
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Urease Inhibitors Weaken the Efficiency of Nitrification Inhibitors in Mitigating N2O Emissions from Soils Irrigated with Alternative Water Resources [PDF]
It is generally accepted that inhibitors are effective in reducing agricultural nitrous oxide (N2O) emissions from soils irrigated by groundwater. However, it was unclear whether these inhibitors effectively regulate N2O emissions from soils irrigated ...
Li, S. +8 more
core +1 more source
Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I [PDF]
, 2012 Background: Chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymphatic leukemia (Ph + ALL) are caused by the t(9;22), which fuses BCR to ABL resulting in deregulated ABL-tyrosine kinase activity.
Ruimi, Nili +18 more
core +1 more source
Drugging the Small GTPase Pathways in Cancer Treatment: Promises and Challenges
Cells, 2019 Small GTPases are a family of low molecular weight GTP-hydrolyzing enzymes that cycle between an inactive state when bound to GDP and an active state when associated to GTP.
Néstor Prieto-Dominguez +2 more
doaj +1 more source