Results 151 to 160 of about 6,774,149 (386)

Global Effects of Kinase Inhibitors on Signaling Networks Revealed by Quantitative Phosphoproteomics [PDF]

, 2009
Cuiping Pan, Jesper V. Olsen, Henrik Daub, Matthias Mann   +3 more
openalex   +1 more source

A Magnetic Surfactant Having One Degree of Unsaturation in the Hydrophobic Tail as a Shale Swelling Inhibitor [PDF]

, 2023
Mobeen Murtaza, Afeez Gbadamosi, Hafiz Mudaser Ahmad, Syed Muhammad Shakil Hussain, Muhammad Shahzad Kamal, Mohamed Mahmoud, Shirish Patil   +6 more
openalex   +1 more source

CFTR Inhibitors

Current Pharmaceutical Design, 2013
The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a cAMP-regulated Cl- channel whose major function is to facilitate epithelial fluid secretion. Loss-of-function mutations in CFTR cause the genetic disease cystic fibrosis. CFTR is required for transepithelial fluid transport in certain secretory diarrheas, such as cholera, and ...
Verkman, Alan S, Synder, David, Tradtrantip, Lukmanee, Thiagarajah, Jay R, Anderson, Marc O   +4 more
openaire   +4 more sources

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Development of mutation-selective LRRK2 kinase inhibitors as precision medicine for Parkinson's disease and other diseases for which carriers are at increased risk

Frontiers in Neurology, 2022
Robert K. Lesniak, Robert K. Lesniak, R. Jeremy Nichols, Thomas J. Montine   +3 more
doaj   +1 more source

Structure-based inhibitors of amyloid beta core suggest a common interface with tau. [PDF]

, 2019
Alzheimer's disease (AD) pathology is characterized by plaques of amyloid beta (Aβ) and neurofibrillary tangles of tau. Aβ aggregation is thought to occur at early stages of the disease, and ultimately gives way to the formation of tau tangles which ...
Bowler, Jeannette, Cascio, Duilio, Eisenberg, David S, Glabe, Charles G, Gonen, Tamir, Griner, Sarah L, Murray, Kevin A, Philipp, Stephan, Rodriguez, Jose A, Sahay, Shruti, Sawaya, Michael R, Seidler, Paul, Sosna, Justyna, Yang, Tianxiao Peter   +13 more
core   +1 more source

Topical Calcineurin Inhibitors for Atopic Dermatitis: Review and Treatment Recommendations [PDF]

, 2013
Warner Carr
openalex   +1 more source

Effectiveness and safety of radiotherapy plus programmed death-1 inhibitors and lenvatinib in patients with advanced biliary tract carcinoma: a real-world study [PDF]

, 2023
Yunchao Wang, Xiaobo Yang, Yanyu Wang, Jingnan Xue, Nan Zhang, Xu Yang, Ning Cong, Junwei Zhang, Chengpei Zhu, Longhao Zhang, Xiaorong Hou, Haitao Zhao   +11 more
openalex   +1 more source

Cholinesterase inhibitors as Alzheimer's therapeutics

Molecular Medicine Reports, 2019
Alzheimer's disease (AD) is one of the most common forms of dementia. AD is a chronic syndrome of the central nervous system that causes a decline in cognitive function and language ability.
K. Sharma
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source