Results 311 to 320 of about 5,057,415 (322)

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

Nature, 2020
Zhenming Jin, Xiaoyu Du, Yechun Xu, Yongqiang Deng, Meiqin Liu, Yao Zhao, Bing Zhang, Xiaofeng Li, Lei-ke Zhang, Chao Peng, Yinkai Duan, Jing Yu, Lin Wang, Kailin Yang, Fengjiang Liu, Ren-di Jiang, Xinglou Yang, Tian You, Xiaoce Liu, Xiuna Yang, Fang Bai, Hong Liu, Xiang Liu, L. Guddat, Wenqing Xu, Gengfu Xiao, C. Qin, Zhènglì Shí, Hualiang Jiang, Z. Rao, Haitao Yang   +30 more
semanticscholar   +1 more source

Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations

Science, 2002
For at least 30 years, matrix metalloproteinases (MMPs) have been heralded as promising targets for cancer therapy on the basis of their massive up-regulation in malignant tissues and their unique ability to degrade all components of the extracellular ...
L. Coussens, B. Fingleton, L. Matrisian
semanticscholar   +1 more source

PD-L1 as a biomarker of response to immune-checkpoint inhibitors

Nature Reviews Clinical Oncology, 2021
D. Doroshow, S. Bhalla, M. Beasley, L. Sholl, K. Kerr, S. Gnjatic, I. Wistuba, D. Rimm, M. Tsao, F. Hirsch   +9 more
semanticscholar   +1 more source

Understanding and overcoming resistance to PARP inhibitors in cancer therapy

Nature Reviews Clinical Oncology, 2021
M. Dias, Sarah C. Moser, S. Ganesan, J. Jonkers   +3 more
semanticscholar   +1 more source

Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?

Nature Reviews Microbiology, 2005
K. Brogden
semanticscholar   +1 more source

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

Nature, 2005
H. Bryant, N. Schultz, H. Thomas, Kayan M. Parker, Dan Flower, Elena Lopez, S. Kyle, M. Meuth, N. Curtin, T. Helleday   +9 more
semanticscholar   +1 more source

Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors

Nature Reviews Clinical Oncology, 2020
L. Galluzzi, Juliette Humeau, A. Buqué, L. Zitvogel, G. Kroemer   +4 more
semanticscholar   +1 more source

SGLT2 inhibitors: mechanisms of cardiovascular benefit beyond glycaemic control

Nature Reviews Cardiology, 2020
M. Cowie, M. Fisher
semanticscholar   +1 more source

Anticancer activities of histone deacetylase inhibitors

Nature reviews. Drug discovery, 2006
Jessica E. Bolden, M. Peart, R. Johnstone   +2 more
semanticscholar   +1 more source

Deep learning enables rapid identification of potent DDR1 kinase inhibitors

Nature Biotechnology, 2019
A. Zhavoronkov, Y. Ivanenkov, A. Aliper, M. Veselov, V. Aladinskiy, Anastasiya V Aladinskaya, V. Terentiev, Daniil Polykovskiy, Maksim Kuznetsov, Arip Asadulaev, Yury Volkov, Artem Zholus, Shayakhmetov Rim, Alexander Zhebrak, L. Minaeva, B. Zagribelnyy, Lennart H Lee, R. Soll, D. Madge, Li Xing, Tao Guo, Alán Aspuru-Guzik   +21 more
semanticscholar   +1 more source