Results 311 to 320 of about 6,512,999 (388)

Multidrug Resistance: Are We Still Afraid of the Big Bad Wolf. [PDF]

Pharmaceuticals (Basel)
Alhazza A, Oyegbesan A, Bousoik E, Montazeri Aliabadi H.   +3 more
europepmc   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Enhanced immunocompatibility and hemocompatibility of nanomedicines across multiple species using complement pathway inhibitors. [PDF]

Sci Adv
Li Y, Jacques S, Gaikwad H, Nebbia M, Banda NK, Holers VM, Tomlinson SA, Scheinman RI, Monte A, Saba L, Lasda E, Hasselberth J, Busquet N, Zelek WM, Moghimi SM, Simberg D.   +15 more
europepmc   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Targeting CDKs in cancer therapy: advances in PROTACs and molecular glues. [PDF]

NPJ Precis Oncol
Marei HE, Bedair K, Hasan A, Al-Mansoori L, Gaiba A, Morrione A, Cenciarelli C, Giordano A.   +7 more
europepmc   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

PLpro Inhibitors as a Potential Treatment for COVID-19. [PDF]

Biomedicines
Han Y, Xu F.
europepmc   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

One step further in targeting acute leukemia by combining antibody-based immunotherapies and small molecule inhibitors. [PDF]

Cancer Cell Int
Dozandeh-Jouybari A, Rohaninia E, Faaliat S, Joudaki N, Ghandi S, Moghaddam MT, Taghiloo S, Kazemi T.   +7 more
europepmc   +1 more source

Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification

FEBS Open Bio, EarlyView.
Chronic kidney disease (CKD) patients often suffer from intestinal and/or mineral and bone disorders. Using a rat model, we showed that uremic vascular calcification is associated with gut barrier alterations (decreased gut mucus production and Nlrp6 gene expression, increased gut inflammation), and plasma retention of gut‐origin uremic toxins (indoxyl
Piotr Bartochowski, Irene Cortijo, Shruti Bhargava, Bernard Jover, Fabrice Raynaud, Juliana H Boukhaled, Anne‐Dominique Lajoix, Vera Jankowski, Joachim Jankowski, Magali Cordaillat‐Simmons, Àngel Argilés, Nathalie Gayrard, Flore Duranton, Jonas Laget   +13 more
wiley   +1 more source