Results 51 to 60 of about 6,774,149 (386)
Novel Insight into the in vivo Function of Mast Cell Chymase: Lessons from Knockouts and Inhibitors
Journal of Innate Immunity, 2020 Mast cells are now recognized as key players in diverse pathologies, but the mechanisms by which they contribute in such settings are only partially understood.
Gunnar Pejler
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Molecules, 2021 The COVID-19 outbreak has rapidly spread on a global scale, affecting the economy and public health systems throughout the world. In recent years, peptide-based therapeutics have been widely studied and developed to treat infectious diseases, including ...
Marjorie C. L. C. Freire +19 more
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Inhibitors of mammalian G1 cyclin-dependent kinases.
Genes & Development, 1995 Biologic machines need brakes, and the nature and fidelity of their operation cannot be unraveled without some prior understanding of how accelerators work. The discoveD] of mammalian G1 cyclins just 4 years ago and the identification of their associated
C. Sherr, James M. Roberts
semanticscholar +1 more source
Understand KRAS and the Quest for Anti-Cancer Drugs
Cells, 2021 The KRAS oncogene is mutated in approximately ~30% of human cancers, and the targeting of KRAS has long been highlighted in many studies. Nevertheless, attempts to target KRAS directly have been ineffective.
Chang Woo Han, Mi Suk Jeong, Se Bok Jang
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Emerging therapeutic opportunities for integrin inhibitors
Nature reviews. Drug discovery, 2021 Integrins are cell adhesion and signalling proteins crucial to a wide range of biological functions. Effective marketed treatments have successfully targeted integrins αIIbβ3, α4β7/α4β1 and αLβ2 for cardiovascular diseases, inflammatory bowel disease ...
R. Slack +4 more
semanticscholar +1 more source
Acquired Haemophilia A: A Review of What We Know
Journal of Blood Medicine, 2022 María Eva Mingot-Castellano,1 Francisco Javier Rodríguez-Martorell,1 Ramiro José Nuñez-Vázquez,1 Pascual Marco2 1Hematology Department, Hospital Universitario Virgen del Rocío. Instituto de Biomedicina de Sevilla (IBIS), Sevilla, Spain; 2General Medicine
Mingot-Castellano ME +3 more
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Discovery of small molecule inhibitors of Leishmania braziliensis Hsp90 chaperone
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Leishmaniasis is a neglected disease caused by the protozoa Leishmania ssp. Environmental differences found by the parasites in the vector and the host are translated into cellular stress, leading to the production of heat shock proteins (Hsp). These are
Fernanda A. H. Batista +7 more
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Molecules, 2022 Since the time of its appearance until present, COVID-19 has spread worldwide, with over 71 million confirmed cases and over 1.6 million deaths reported by the World Health Organization (WHO). In addition to the fact that cases of COVID-19 are increasing
Anthi Petrou +6 more
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Comparison of nitrification inhibitors to restrict nitrate leaching in a maize crop irrigated under mediterranean conditions [PDF]
, 2010 The aim of this paper was to compare dicyandiamide (DCD) and 3,4 dimethylpyrazole phosphate (DMPP) as inhibitors of ammonium oxidation and nitrate leaching after applying fertilizer to a maize (Zea mays L.) crop grown under Mediterranean conditions.
Arauzo, M. +4 more
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Cell Death & Differentiation, 1999 Caspases are the key effector molecules of the physiological death process known as apoptosis, although some are involved in activation of cytokines, rather than cell death. They exist in most of our cells as inactive precursors (zymogens) that kill the cell once activated. Caspases can be controlled in two ways.
P G, Ekert, J, Silke, D L, Vaux
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