Results 31 to 40 of about 2,374,405 (307)

Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication

Viruses, 2015
The current outbreak of Ebola virus (EBOV) in West Africa has claimed the lives of more than 15,000 people and highlights an urgent need for therapeutics capable of preventing virus replication.
Olivier Reynard, Xuan-Nhi Nguyen, Nathalie Alazard-Dany, Véronique Barateau, Andrea Cimarelli, Viktor E. Volchkov   +5 more
doaj   +1 more source

Understand KRAS and the Quest for Anti-Cancer Drugs

Cells, 2021
The KRAS oncogene is mutated in approximately ~30% of human cancers, and the targeting of KRAS has long been highlighted in many studies. Nevertheless, attempts to target KRAS directly have been ineffective.
Chang Woo Han, Mi Suk Jeong, Se Bok Jang
doaj   +1 more source

Protease inhibitors prevent plasminogen-mediated, but not pemphigus vulgaris-induced, acantholysis in human epidermis [PDF]

, 2003
Pemphigus is an autoimmune blistering disease of the skin and mucous membranes. It is caused by autoantibodies directed against desmosomes, which are the principal adhesion structures between epidermal keratinocytes.
Besch, R., Wosikowski, K., Probst, C., Sander, C. A., Degitz, K., Schuh, T., Flaig, M. J., Braungart, E., Douwes, K., Magdolen, V., C.A. Sander, C. Probst, K. Wosikowski, K. Degitz, T. Schuh, R. Besch, E. Braungart, V. Magdolen, M.J. Flaig, K. Douwes   +19 more
core   +2 more sources

Thiazole/Thiadiazole/Benzothiazole Based Thiazolidin-4-One Derivatives as Potential Inhibitors of Main Protease of SARS-CoV-2

Molecules, 2022
Since the time of its appearance until present, COVID-19 has spread worldwide, with over 71 million confirmed cases and over 1.6 million deaths reported by the World Health Organization (WHO). In addition to the fact that cases of COVID-19 are increasing
Anthi Petrou, Panagiotis Zagaliotis, Nikoleta F. Theodoroula, George A. Mystridis, Ioannis S. Vizirianakis, Thomas J. Walsh, Athina Geronikaki   +6 more
doaj   +1 more source

High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase [PDF]

, 2011
<p><b>Background:</b> <i>Leishmania</i> species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs).
Mottram Jeremy C., Thomson, Graeme, Mottram, JC, Grant Karen M., Turner, N.J., Malcolm D. Walkinshaw, Malone, Kirk, Turner, Nicholas J., Nicholas J Turner, Jeremy C. Mottram, Karen M. Grant, Walker, Roderick G., Kita, K, Graeme Thomson, Malone Kirk, Karen M Grant, Grant, Karen, Nicholas J. Turner, Walker, RG, Nowicki, Matthew W., Thomson Graeme, Walkinshaw, M.D., Walkinshaw Malcolm D., David G. Blake, David G Blake, Walker Roderick G., Brown, Elaine, Brown Elaine, Blake David G., Brown, E, Malone, K, Turner Nicholas J., Walkinshaw, MD, Blake, DG, Matthew W. Nowicki, Walker, R.G., Malone, K., Blake, David G., Elaine Brown, Mottram, J.C., Kirk Malone, Walkinshaw, Malcolm D., Matthew W Nowicki, Nowicki, MW, Brown, E., Nowicki Matthew W., Turner, Nicholas J.; id_orcid, Grant, Karen M., Grant, K.M., Mottram, Jeremy C., Roderick G Walker, Thomson, G, Jeremy C Mottram, Roderick G. Walker, Nowicki, M.W., Grant, KM, Blake, D.G., Malcolm D Walkinshaw, Turner, NJ, Thomson, G.   +59 more
core   +2 more sources

Acquired Haemophilia A: A Review of What We Know

Journal of Blood Medicine, 2022
María Eva Mingot-Castellano,1 Francisco Javier Rodríguez-Martorell,1 Ramiro José Nuñez-Vázquez,1 Pascual Marco2 1Hematology Department, Hospital Universitario Virgen del Rocío. Instituto de Biomedicina de Sevilla (IBIS), Sevilla, Spain; 2General Medicine
Mingot-Castellano ME, Rodríguez-Martorell FJ, Nuñez-Vázquez RJ, Marco P   +3 more
doaj  

Discovery of small molecule inhibitors of Leishmania braziliensis Hsp90 chaperone

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Leishmaniasis is a neglected disease caused by the protozoa Leishmania ssp. Environmental differences found by the parasites in the vector and the host are translated into cellular stress, leading to the production of heat shock proteins (Hsp). These are
Fernanda A. H. Batista, Sérgio L. Ramos, Giusy Tassone, Andrei Leitão, Carlos A. Montanari, Maurizio Botta, Mattia Mori, Júlio C. Borges   +7 more
doaj   +1 more source

The STING in Non-Alcoholic Fatty Liver Diseases: Potential Therapeutic Targets in Inflammation-Carcinogenesis Pathway

Pharmaceuticals, 2022
Non-alcoholic fatty liver disease (NAFLD), an important chronic disease, is one of the major causes of high mortality and creates a substantial financial burden worldwide.
Juan Lv, Chunlei Xing, Yuhong Chen, Huihui Bian, Nanning Lv, Zhibin Wang, Mingming Liu, Li Su   +7 more
doaj   +1 more source

beta-lactamase-inhibitors

, 2022
Archive of beta-lactamase-inhibitors containing sub-folders named after each compound and its net charge. Every compound's folder contains a total of 20 files distributed into three sub-directories reporting QM (QM/), FF (FF/), and MD (MD ...
Giuliano Malloci (2060875), Silvia Gervasoni (6169202), Andrea Bosin (6743129), Helen I. Zgurskaya (3093648), Attilio Vittorio Vargiu (2358538), Paolo Ruggerone (247673)   +5 more
core   +1 more source

A class of carbonic anhydrase I – selective activators

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
A series of ureido and bis-ureido derivatives were prepared by reacting histamine with alkyl/aryl-isocyanates or di-isocyanates. The obtained derivatives were assayed as activators of the enzyme carbonic anhydrase (CA, EC 4.2.1.1), due to the fact that ...
Erol Licsandru, Muhammet Tanc, Istvan Kocsis, Mihail Barboiu, Claudiu T. Supuran   +4 more
doaj   +1 more source