Results 31 to 40 of about 2,437,359 (310)
Frontiers in Microbiology, 2019 We report the successful implementation of virtual screening in the discovery of new inhibitors of undecaprenyl pyrophosphate synthase (UppS) from Escherichia coli. UppS is an essential enzyme in the biosynthesis of bacterial cell wall.
Marko Jukič +4 more
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Frontiers in Chemistry, 2022 Activated Cdc42-associated kinase 1 (ACK1/TNK2) has a significant role in cell endocytosis, survival, proliferation, and migration. Mutations in ACK1 are closely associated with the occurrence and development of cancers.
Ruby Srivastava
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Research Progress of Squalene Monooxygenase and Cancer
Zhongliu Fangzhi Yanjiu, 2023 Squalene monooxygenase (SQLE) is the rate-limiting enzyme of cholesterol biosynthesis. It plays a crucial role in regulating cholesterol homeostasis. Increasing evidence shows that SQLE is closely related to the occurrence, development, metastasis, and ...
GUO Liangqi, LIU Yayun, SHENG Deqiao
doaj +1 more source
FGF19–FGFR4 Signaling in Hepatocellular Carcinoma
Cells, 2019 Hepatocellular carcinoma (HCC) is the sixth most common type of cancer, with an increasing mortality rate. Aberrant expression of fibroblast growth factor 19−fibroblast growth factor receptor 4 (FGF19−FGFR4) is reported to be an oncogenic ...
Aroosha Raja +3 more
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ChemistryOpen, 2020 Insulin‐regulated aminopeptidase (IRAP) is a new potential macromolecular target for drugs aimed for treatment of cognitive disorders. Inhibition of IRAP by angiotensin IV (Ang IV) improves the memory and learning in rats.
Karin Engen +10 more
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Monoamine Oxidase (MAO) as a Potential Target for Anticancer Drug Design and Development
Molecules, 2021 Monoamine oxidases (MAOs) are oxidative enzymes that catalyze the conversion of biogenic amines into their corresponding aldehydes and ketones through oxidative deamination.
Reem Aljanabi +5 more
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Biomedicines, 2021 The coronavirus disease 2019 (COVID-19) pandemic severely impacts health, economy, and society worldwide. Antiviral drugs against SARS-CoV-2 are urgently needed to cope with this global crisis. It has been found that the biogenesis and release mechanisms
Supasek Kongsomros +9 more
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Novel Insight into the in vivo Function of Mast Cell Chymase: Lessons from Knockouts and Inhibitors
Journal of Innate Immunity, 2020 Mast cells are now recognized as key players in diverse pathologies, but the mechanisms by which they contribute in such settings are only partially understood.
Gunnar Pejler
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Molecules, 2021 The COVID-19 outbreak has rapidly spread on a global scale, affecting the economy and public health systems throughout the world. In recent years, peptide-based therapeutics have been widely studied and developed to treat infectious diseases, including ...
Marjorie C. L. C. Freire +19 more
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Lipopeptides as dimerization inhibitors of HIV-1 protease [PDF]
, 1999 In AIDS therapy, attempts have been made to inhibit the virus-encoded enzymes, e.g, HIV-1 protease, using active site-directed inhibitors. This approach is questionable, however, due to virus mutations and the high toxicity of the drugs, An alternative ...
Schramm, W. +5 more
core +1 more source