Results 21 to 30 of about 2,437,359 (310)

Fluorescent Reporters and Biosensors for Probing the Dynamic Behavior of Protein Kinases

Proteomes, 2015
Probing the dynamic activities of protein kinases in real-time in living cells constitutes a major challenge that requires specific and sensitive tools tailored to meet the particular demands associated with cellular imaging.
Juan A. González-Vera, May C. Morris
doaj   +1 more source

Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]

, 2003
Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Sato, Sumito, Assfalg-Machleidt, Irmgard, Magdolen, Ulla, Schmitt, Manfred, Rettenberger, Peter, Magdolen, Viktor, Krol, Janna   +6 more
core   +1 more source

Development process for eco-friendly corrosion inhibitors

, 2022
Currently, the eco-friendly corrosion inhibitors are widely used to protect the metallic materials from the corrosion destruction. The eco-friendly corrosion inhibitors are biodegradable, low toxic, low volatile, low cost, good water soluble, good ...
Dagdag, Omar, Rbaa, Mohamed, Galai, Mouhsine, Guo, Lei, Zarrouk, Abdelkader, Berdimurodov, Elyor, Tüzün, Burak   +6 more
core   +1 more source

Natural Polymers as Corrosion Inhibitors [PDF]

, 2021
Can something as natural as a plant exudate prevent a piece of iron from rusting? In the previous years, to achieve highly efficient corrosion protection of industrial equipment and common metallic objects, synthetic compounds were used as corrosion ...
Rizvi Marziya, Marziya Rizvi
core   +1 more source

Discovery and validation of SIRT2 inhibitors based on tenovin-6 : use of a 1H-NMR method to assess deacetylase activity [PDF]

, 2012
The search for potent and selective sirtuin inhibitors continues as chemical tools of this type are of use in helping to assign the function of this interesting class of deacetylases.
Pirrie, L, Sonia Lain, Major, LL, Zubriene, Asta, Lebl, T, Matulis, Daumantas, Lisa Pirrie, Morkunaite, Vaida, Tomas Lebl, McCarthy, Anna R., Asta Zubrienė, Louise L. Major, Matulis, D, Lain, Sonia, Daumantas Matulis, Morkunaite, V, Nicholas J. Westwood, Vaida Morkūnaitė, Major, Louise L., Westwood, NJ, Anna R. McCarthy, McCarthy, AR, Zubriene, A, Lebl, Tomas, Lain, S, Westwood, Nicholas J., Pirrie, Lisa, Major, Louise L.; id_orcid, Westwood, Nicholas J.; id_orcid, Lebl, Tomas; id_orcid   +29 more
core   +1 more source

Multifunctional Donepezil Analogues as Cholinesterase and BACE1 Inhibitors

Molecules, 2018
A series of 22 donepezil analogues were synthesized through alkylation/benzylation and compared to donepezil and its 6-O-desmethyl adduct. All the compounds were found to be potent inhibitors of both acetylcholinesterase (AChE) and butyrylcholinesterase (
Keith D. Green, Marina Y. Fosso, Sylvie Garneau-Tsodikova   +2 more
doaj   +1 more source

beta-lactamase-inhibitors

, 2022
Archive of beta-lactamase-inhibitors containing sub-folders named after each compound and its net charge. Every compound's folder contains a total of 20 files distributed into three sub-directories reporting QM (QM/), FF (FF/), and MD (MD ...
Giuliano Malloci (2060875), Silvia Gervasoni (6169202), Andrea Bosin (6743129), Helen I. Zgurskaya (3093648), Attilio Vittorio Vargiu (2358538), Paolo Ruggerone (247673)   +5 more
core   +1 more source

Review of PD-1/PD-L1 Inhibitors in Metastatic dMMR/MSI-H Colorectal Cancer

Frontiers in Oncology, 2019
There are a wide range of therapies for metastatic colorectal cancer (CRC) available, but outcomes remain suboptimal. Learning the role of the immune system in cancer development and progression led to advances in the treatment over the last decade ...
André F. Oliveira, Luís Bretes, Irene Furtado   +2 more
doaj   +1 more source

Organic and Inorganic Corrosion Inhibitors

, 2021
Organic and inorganic compounds are widely used as corrosion inhibitors. It is important to mention that most of the inorganic compounds are toxic and non-environmental friendly; therefore, their current use as corrosion inhibitors is strictly inhibited ...
Savaş Kaya, Serdaroğlu, Goncagül, Goncagül Serdaroğlu, Kaya, Savaş   +3 more
core   +1 more source

A comparative evaluation of NB30, NB54 and PTC124 in translational read‐through efficacy for treatment of an USH1C nonsense mutation

EMBO Molecular Medicine, 2012
Translational read‐through‐inducing drugs (TRIDs) promote read‐through of nonsense mutations, placing them in the spotlight of current gene‐based therapeutic research.
Tobias Goldmann, Nora Overlack, Fabian Möller, Valery Belakhov, Michiel van Wyk, Timor Baasov, Uwe Wolfrum, Kerstin Nagel‐Wolfrum   +7 more
doaj   +1 more source