Results 21 to 30 of about 2,374,405 (307)
Research Progress of Squalene Monooxygenase and Cancer
Zhongliu Fangzhi Yanjiu, 2023 Squalene monooxygenase (SQLE) is the rate-limiting enzyme of cholesterol biosynthesis. It plays a crucial role in regulating cholesterol homeostasis. Increasing evidence shows that SQLE is closely related to the occurrence, development, metastasis, and ...
GUO Liangqi, LIU Yayun, SHENG Deqiao
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Discovery and validation of SIRT2 inhibitors based on tenovin-6 : use of a 1H-NMR method to assess deacetylase activity [PDF]
, 2012 The search for potent and selective sirtuin inhibitors continues as chemical tools of this type are of use in helping to assign the function of this interesting class of deacetylases.
Pirrie, L +26 more
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FGF19–FGFR4 Signaling in Hepatocellular Carcinoma
Cells, 2019 Hepatocellular carcinoma (HCC) is the sixth most common type of cancer, with an increasing mortality rate. Aberrant expression of fibroblast growth factor 19−fibroblast growth factor receptor 4 (FGF19−FGFR4) is reported to be an oncogenic ...
Aroosha Raja +3 more
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ChemistryOpen, 2020 Insulin‐regulated aminopeptidase (IRAP) is a new potential macromolecular target for drugs aimed for treatment of cognitive disorders. Inhibition of IRAP by angiotensin IV (Ang IV) improves the memory and learning in rats.
Karin Engen +10 more
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Monoamine Oxidase (MAO) as a Potential Target for Anticancer Drug Design and Development
Molecules, 2021 Monoamine oxidases (MAOs) are oxidative enzymes that catalyze the conversion of biogenic amines into their corresponding aldehydes and ketones through oxidative deamination.
Reem Aljanabi +5 more
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Biomedicines, 2021 The coronavirus disease 2019 (COVID-19) pandemic severely impacts health, economy, and society worldwide. Antiviral drugs against SARS-CoV-2 are urgently needed to cope with this global crisis. It has been found that the biogenesis and release mechanisms
Supasek Kongsomros +9 more
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Differential in vitro and in vivo effect of barley cysteine and serine protease inhibitors on phytopathogenic microorganisms [PDF]
, 2011 Protease inhibitors from plants have been involved in defence mechanisms against pests and pathogens. Phytocystatins and trypsin/α-amylase inhibitors are two of the best characterized protease inhibitor families in plants.
Cambra Marin, Ines +5 more
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Novel Insight into the in vivo Function of Mast Cell Chymase: Lessons from Knockouts and Inhibitors
Journal of Innate Immunity, 2020 Mast cells are now recognized as key players in diverse pathologies, but the mechanisms by which they contribute in such settings are only partially understood.
Gunnar Pejler
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Molecules, 2021 The COVID-19 outbreak has rapidly spread on a global scale, affecting the economy and public health systems throughout the world. In recent years, peptide-based therapeutics have been widely studied and developed to treat infectious diseases, including ...
Marjorie C. L. C. Freire +19 more
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Differential effects of low molecular weight inhibitors on the conformation and the immunologic function of the adhesion receptor LFA-1 [PDF]
, 2004 Previous studies of our group 1,2 and by others 3 on the isolated ligand binding domain of LFA-1 (αL I domain) have suggested that some LFA-1 inhibitors act allosterically while other inhibitors were proposed to competitively block the LFA- 1/ligand ...
Welzenbach, Karl Albert
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