Results 11 to 20 of about 1,707,314 (269)

Review of PD-1/PD-L1 Inhibitors in Metastatic dMMR/MSI-H Colorectal Cancer

Frontiers in Oncology, 2019
There are a wide range of therapies for metastatic colorectal cancer (CRC) available, but outcomes remain suboptimal. Learning the role of the immune system in cancer development and progression led to advances in the treatment over the last decade ...
André F. Oliveira, Luís Bretes, Irene Furtado   +2 more
doaj   +1 more source

A comparative evaluation of NB30, NB54 and PTC124 in translational read‐through efficacy for treatment of an USH1C nonsense mutation

EMBO Molecular Medicine, 2012
Translational read‐through‐inducing drugs (TRIDs) promote read‐through of nonsense mutations, placing them in the spotlight of current gene‐based therapeutic research.
Tobias Goldmann, Nora Overlack, Fabian Möller, Valery Belakhov, Michiel van Wyk, Timor Baasov, Uwe Wolfrum, Kerstin Nagel‐Wolfrum   +7 more
doaj   +1 more source

Anthranilic Acid Inhibitors of Undecaprenyl Pyrophosphate Synthase (UppS), an Essential Enzyme for Bacterial Cell Wall Biosynthesis

Frontiers in Microbiology, 2019
We report the successful implementation of virtual screening in the discovery of new inhibitors of undecaprenyl pyrophosphate synthase (UppS) from Escherichia coli. UppS is an essential enzyme in the biosynthesis of bacterial cell wall.
Marko Jukič, Kaja Rožman, Matej Sova, Hélène Barreteau, Stanislav Gobec   +4 more
doaj   +1 more source

Chemical Reactivity and Optical and Pharmacokinetics Studies of 14 Multikinase Inhibitors and Their Docking Interactions Toward ACK1 for Precision Oncology

Frontiers in Chemistry, 2022
Activated Cdc42-associated kinase 1 (ACK1/TNK2) has a significant role in cell endocytosis, survival, proliferation, and migration. Mutations in ACK1 are closely associated with the occurrence and development of cancers.
Ruby Srivastava
doaj   +1 more source

Research Progress of Squalene Monooxygenase and Cancer

Zhongliu Fangzhi Yanjiu, 2023
Squalene monooxygenase (SQLE) is the rate-limiting enzyme of cholesterol biosynthesis. It plays a crucial role in regulating cholesterol homeostasis. Increasing evidence shows that SQLE is closely related to the occurrence, development, metastasis, and ...
GUO Liangqi, LIU Yayun, SHENG Deqiao
doaj   +1 more source

FGF19–FGFR4 Signaling in Hepatocellular Carcinoma

Cells, 2019
Hepatocellular carcinoma (HCC) is the sixth most common type of cancer, with an increasing mortality rate. Aberrant expression of fibroblast growth factor 19−fibroblast growth factor receptor 4 (FGF19−FGFR4) is reported to be an oncogenic ...
Aroosha Raja, Inkeun Park, Farhan Haq, Sung-Min Ahn   +3 more
doaj   +1 more source

Synthesis, Evaluation and Proposed Binding Pose of Substituted Spiro‐Oxindole Dihydroquinazolinones as IRAP Inhibitors

ChemistryOpen, 2020
Insulin‐regulated aminopeptidase (IRAP) is a new potential macromolecular target for drugs aimed for treatment of cognitive disorders. Inhibition of IRAP by angiotensin IV (Ang IV) improves the memory and learning in rats.
Karin Engen, Dr. Sudarsana Reddy Vanga, Dr. Thomas Lundbäck, Dr. Faith Agalo, Vivek Konda, Dr. Annika Jenmalm Jensen, Prof. Johan Åqvist, Dr. Hugo Gutiérrez‐de‐Terán, Prof. Dr. Mathias Hallberg, Prof. Dr. Mats Larhed, Dr. Ulrika Rosenström   +10 more
doaj   +1 more source

Monoamine Oxidase (MAO) as a Potential Target for Anticancer Drug Design and Development

Molecules, 2021
Monoamine oxidases (MAOs) are oxidative enzymes that catalyze the conversion of biogenic amines into their corresponding aldehydes and ketones through oxidative deamination.
Reem Aljanabi, Lina Alsous, Dima A. Sabbah, Halise Inci Gul, Mustafa Gul, Sanaa K. Bardaweel   +5 more
doaj   +1 more source

Anti-SARS-CoV-2 Activity of Extracellular Vesicle Inhibitors: Screening, Validation, and Combination with Remdesivir

Biomedicines, 2021
The coronavirus disease 2019 (COVID-19) pandemic severely impacts health, economy, and society worldwide. Antiviral drugs against SARS-CoV-2 are urgently needed to cope with this global crisis. It has been found that the biogenesis and release mechanisms
Supasek Kongsomros, Ampa Suksatu, Phongthon Kanjanasirirat, Suwimon Manopwisedjaroen, Somsak Prasongtanakij, Kedchin Jearawuttanakul, Suparerk Borwornpinyo, Suradej Hongeng, Arunee Thitithanyanont, Somchai Chutipongtanate   +9 more
doaj   +1 more source

Novel Insight into the in vivo Function of Mast Cell Chymase: Lessons from Knockouts and Inhibitors

Journal of Innate Immunity, 2020
Mast cells are now recognized as key players in diverse pathologies, but the mechanisms by which they contribute in such settings are only partially understood.
Gunnar Pejler
doaj   +1 more source