Results 121 to 130 of about 7,577,140 (312)

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Environment-Dependent Dimerization as a Functional Switch in Leech Cystatin CysHv

Toxins
Cystatins from hematophagous organisms modulate host proteases and are promising biotechnological tools. CysHv, a secreted cystatin from the Brazilian leech Haementeria vizottoi, was previously characterized as a potent inhibitor of papain and cathepsin ...
Melissa Regina Fessel, Ana Marisa Chudzinski-Tavassi, Fernanda Faria   +2 more
doaj   +1 more source

The inhibitory effect of intestinal bacterial metabolite of ginsenosides on CYP3A activity

, 2004
The intestinal bacterial metabolites of ginsenosides are responsible for the main pharmacological activities of ginseng. The purpose of this study was to find whether these metabolites influence hepatic metabolic enzymes and to predict the potential for ...
Liu, Y, Li, P, Yang, SL, Li, W, Yang, L, Deng, MC   +5 more
core  

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Growth-inhibitory activity of Sal on HCC cells.

, 2013
Growth-inhibitory activity of Sal on HCC cells.
Fan Wang (135182), Ling Xu (117663), Ying-Qun Zhou (292696), Dong Wu (140590), Jie Lu (139953), Ping Cheng (289811), Shu-Mei Wu (292692), Yan Zhang (8098), Wei-Qi Dai (292686), Miao Shen (292694), Chen-Feng Wang (292695), Chun-Lei Lin (292690), Xuan-Fu Xu (292698), Lei He (143930), Ya-Ping Xu (292688), Chuan-Yong Guo (292699)   +15 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Inhibition of Streptococcus pneumoniae adenylate kinase by some 5-arylidene-thiazolidin-4-on-2-thione derivates

Romanian Journal of Laboratory Medicine, 2013
Adenilat kinaza este o enzimă ubiquitară prezentă atât la procariote cât şi la eucariote. în această lucrare am testat acţiunea inhibitorie a şase 5-ariliden-tiazolidin-4-on-2-tione faţă de adenilat kinaza din Strepto- coccus pneumoniae (A\Ksp) prin ...
Ionescu Miliaela Ileana, Costache Adriana Z., Oniga Ovidiu, Banciu Horia L., Lupan Iulia   +4 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

KADAR 1-DEOXYNOJIRIMYCIN DAN AKTIFITAS PENGHAMBATAN TERHADAP ENZIM Α-GLUKOSIDASE DALAM EKSTRAK, TEPUNG EKSTRAK DAN TEPUNG INSTANT DAUN MURBAI (Morus alba L) [1-Deoxynojirimycin Content and Inhibitory Activity on Α-Glucosidase Enzyme of Extract, Extract Powder and Instant Powder of Mulberry (Morus alba L)]

Jurnal Teknologi dan Industri Pangan, 2010
Many researcher had proved that the mulberry leaves had effective enzyme inhibitory activity. For easy serving, the leaves had been processed as extract powder and instant powder.
Kesuma Sayuti1)*, Norio Muto2)
doaj