Results 151 to 160 of about 753,617 (295)

Inhibitory effect of alcoholic eucalyptus extract with nanosilver particles on E.coli growth

مجله دانشگاه علوم پزشکی گرگان, 2013
Background and Objective: Nanosilver particles are one of the functional nanotechnology filed. These nanoparticles have antibacterial characteritics. Combination therapy is one of new and specific therapeutic regiment in medicine.
Naghsh N, Soleymani S, Torkan S
doaj  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The dose-response and inhibition curves for the 20% standardized olive leaf extract, which were determined using GraphPad Prism’s nonlinear regression analysis, show the half-maximal cytotoxic concentration (CC₅₀) in Vero E6 cells and the inhibitory concentration 50 percent (IC₅₀) against NRC-03-nhCoV.

The dose-response and inhibition curves for the 20% standardized olive leaf extract, which were determined using GraphPad Prism’s nonlinear regression analysis, show the half-maximal cytotoxic concentration (CC50) in Vero E6 cells and the inhibitory ...
Sara H. Mahmoud (9574701), Eslam B. Elkaeed (9952518), Mahmoud A. El Hassab (9952515), Fatma E. Hassan (12911381), Shimaa M. Abdelgawad (18446578), Wagdy M. Eldehna (4260952), Engy A. Wahsh (15251281), Taghreed A. Majrashi (5991263), Ahmed Mostafa (354419)   +8 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

GABAergic compensation in connexin36 knock-out mice evident during low-magnesium seizure-like event activity

, 2010
Gap junctions within the cerebral cortex may facilitate cortical seizure formation by their ability to synchronize electrical activity. To investigate this, one option is to compare wild-type (WT) animals with those lacking the gene for connexin36 (Cx36 ...
Melin, Sofia M., Jacobson, Gregory M., Voss, Logan J., Sleigh, James W,, Sleigh, James W., Gregory Jacobson, James W. Sleigh, Jacobson, Gregory,, Sofia Melin, Voss, Logan J,, Melin, Sofia,, Logan J. Voss   +11 more
core   +1 more source

DETERMINATION OF DIARRHETIC SHELLFISH TOXINS BY MEASURING 50% ACID PHOSPHATASE ACTIVITY INHIBITORY CONCENTRATION

Mycotoxins, 1988
SHIRAKI, K., SUGITANI, A., KAWAI, M., YASUMOTO, T.   +3 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Role of cGMP as second messenger of adenosine in the inhibition of renin release

, 1988
Adenosine is known to be a potent inhibitor of renin release from the kidneys. The aim of this study was to investigate the transmembrane signalling avenue that the second messenger of adenosine causes inhibition of renal renin release.
Kurtz, Armin, Della Bruna, Roberto, Della Bruna, R., Bauer, Christian, Pfeilschifter, Josef, Pfeilschifter, J.   +5 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

In Vitro Investigations into the Potential Drug Interactions of Pseudoginsenoside DQ Mediated by Cytochrome P450 and Human Drug Transporters

Molecules
Pseudoginsenoside DQ (PDQ), an ocotillol-type ginsenoside, is synthesized with protopanaxadiol through oxidative cyclization. PDQ exhibits good anti-arrhythmia activity.
Zhuo Li, Cuizhu Wang, Jinping Liu, Pingya Li, Hao Feng   +4 more
doaj   +1 more source