Results 131 to 140 of about 7,131,135 (287)

Minimum inhibitory concentration (MIC) of synthetic BcDef1.

, 2018
Minimum inhibitory concentration (MIC) of synthetic BcDef1.
Warunee Hanpithakphong (5587538), Sawang Petvises (523491), Mathira Wongchai (5587535), Siriporn Kaewklom (5587532), Ratchaneewan Aunpad (5587541)   +4 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) in Goat's Milk Kefir Against Pathogenic Microbes

The purpose of this study was to determine the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of goat milk kefir.
Wardhani, Cindy Heryanti Kusuma
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Purification of Acetylcholinesterase from Locusta migratoria and preliminary study on pesticide screening

四川大学学报. 自然科学版, 2018
AChE was purified by affinity chromatography from Locusta migratoria head. The purification factors and yields were 474.81fold and 28.93%, respectively. The molecular weight of the purified enzyme was 67.22kDa, measured by SDSPAGE.
DENG Yuan-Jie, ZHANG Xiao-Xiao, GAO Tian-Tian, TAO Ke, JIN Hong, HOU Tai-Ping   +5 more
doaj  

Inhibitory concentration for 50% reduction in PHE contractile responses (IC₅₀) and Dissociation constants (-K_B) values of α₁-AR subtypes inhibitors for phenylephrine-induced contractility in ovine middle cerebral arteries.

, 2014
Inhibitory concentration for 50% reduction in PHE contractile responses (IC50) and Dissociation constants (-KB) values of α1-AR subtypes inhibitors for phenylephrine-induced contractility in ovine middle cerebral arteries.
Ravi Goyal (499376), Nina Chu (659729), Jonathan Van Wickle (499377), Lawrence D. Longo (499380), Dipali Goyal (499378)   +4 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

INHIBITION OF GARLIC EXTRACT (ALLIUM SATIVUM) IN 50% CONCENTRATION TO STAPHYLOCOCCUS AUREUS BACTERIA (IN VITRO) [PDF]

, 2019
Objective: Periodontal abscess is an inflammatory process that occurs due to a localized bacterial infection involving deeper periodontal structures and may occur acutely or chronically.
POERNOMO, HENDRI, HARYANI, DEWI
core   +1 more source

Half-maximal inhibitory concentration (IC₅₀) values of pyrimidine derivatives MKP106–123 against epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR)-2.

, 2015
Half-maximal inhibitory concentration (IC50) values of pyrimidine derivatives MKP106–123 against epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR)-2.
Jiho Song (799714), Wonhee Suh (799719), Hong Khanh Nguyen (799717), Ara Kwon (799715), Kyung Hoon Min (799720), Doran Kim (799716), Bong-Yong Lee (799718), Jakyung Yoo (406971)   +7 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source