Results 131 to 140 of about 753,617 (295)

Bioactive Potential of Pogostemon benghalensis (Burm.f.) Kuntze: Antibacterial, Antioxidant, and Xanthine Oxidase Inhibitory Activities

Bacteria
This research is focused on assessing the antibacterial properties of Pogostemon benghalensis stem bark and inflorescence extracts, as well as their inhibitory effects on xanthine oxidase, antioxidant potential, overall phenolic content, and flavonoid ...
Nitesh Jaishwal, Mamta Jayswal, Deep Chand Gupta, Bishnu Dhakal, Santosh Koirala, Ram Bahadur Khadka, Hari Prasad Devkota, Jitendra Pandey   +7 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Determination of Minimum Inhibitory Concentration (MIC) and percentage Bacterial Growth Inhibition of essential oils against Gram Positive Bacterial pathogens

, 2019
Essential oils and volatile constituents extracted from Aromatic plants are frequently used in folk medicine for prevention and treatment of different human diseases. The urge to develop alternative treatment strategies follows three different directions.
Saranraj, P., Sivasakthivelan, P., Nagalakshmi, S.   +2 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Half maximal inhibitory concentration values for ZINC01807204 and other β-lactamase inhibitors determined after 5 minute of incubation with KPC-2.

, 2014
IC50 Half maximal inhibitory concentration. Shown as arithematic mean (three repetitions on three separate days).Half maximal inhibitory concentration values for ZINC01807204 and other β-lactamase inhibitors determined after 5 minute of incubation with ...
Asad U. Khan (110840), Mohammad Faheem (380758), Mohd Danishuddin (110825), Arbab Khan (635729)   +3 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Assessment of hydroalcoholic and hexane extracts of Rosa persica Mich. flower on rat ileum spasm

Research in Pharmaceutical Sciences, 2016
It has been reported that Rosa damascena hydroalcoholic extract has inhibitory effect at higher concentration but stimulatory action at lower concentrations on ileum. This could be due to the presence of stimulatory components in the extract. R.
Hassan Sadraei, Gholamreza Asghari, Fatemeh Jalali   +2 more
doaj  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Different inhibitory concentrations (IC) of cisplatin in MS751, ME180 REV3L cells and control cells.

, 2015
IC30, 30% inhibitory concentration of cisplatin; IC50, 50% inhibitory concentration of cisplatin; IC70, 70% inhibitory concentration of cisplatin ...
Gong Yang (216381), Xi Cheng (296756), Tingyan Shi (703918), Chunxia Ren (703919), Xiaoyu Tu (703921), Yingyi Li (703920), Ziliang Wang (482117), Li Yang (6520), Fei Liu (21082)   +8 more
core   +1 more source

Synergistic Effect of Metronidazole and Chlorhexidine against Porphyromonas gingivalis Growth: An In Vitro Study

Dentistry Journal
Aim: To evaluate the potential synergistic activity of metronidazole (MTZ) and chlorhexidine (CHX) against Porphyromonas. gingivalis (P. gingivalis) growth. Methods: Antimicrobial susceptibility tests of P.
Claudia Lorenzi, Fabrizio Lio, Vincenzo Mazzetti, Paolo Carosi, Stefano Lamelza, Enrico Salvatore Pistoia, Francesca Pica, Roberta Gaziano   +7 more
doaj   +1 more source