Results 141 to 150 of about 1,832,210 (358)

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Inhibitory effect of UDP-glucose on cAMP generation and insulin secretion [PDF]

open access: hybrid, 2020
Fariborz Parandeh   +5 more
openalex   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Inhibitory Effect of Hemin-Polymer System Against Escherichia coli and Staphylococcus aureus

open access: yesАнтибиотики и Химиотерапия
Background. Wound infections of bacterial etiology are a socially significant problem. The lack of rational antibiotic therapy can lead to an increase in the emergence of resistant strains of microorganisms.
O. A. Gruznova   +8 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

The inhibitory effect of nociceptin on the micturition reflex in anaesthetized rats

open access: green, 1998
Sandro Giuliani   +3 more
openalex   +2 more sources

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