Results 51 to 60 of about 147,661 (240)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Extracting the Non-ObservableStates in Alignment & Calibration Process for Gimballed Inertial Navigation Systems [PDF]

فصلنامه علوم و فناوری فضایی, 2014
This paper presents a method for calculation the non observable states in alignment and calibration process in gimballed inertial navigation system, using estimation method in static linear system and heuristic optimization algorithms. The non observable
S. M. SalehiAmiri, A. A. Nikkhah, H. Nobahari   +2 more
doaj  

An Improved Alignment Method for the Strapdown Inertial Navigation System (SINS)

Sensors, 2016
In this paper, an innovative inertial navigation system (INS) mechanization and the associated Kalman filter (KF) are developed to implement a fine alignment for the strapdown INS (SINS) on stationary base.
Meng Liu, Yanbin Gao, Guangchun Li, Xingxing Guang, Shutong Li   +4 more
doaj   +1 more source

Range-Doppler domain spatial alignment for networked radars

EURASIP Journal on Advances in Signal Processing, 2022
An important prerequisite for the radar network detection is that the measurements from local radars are transformed to a common reference frame without systematic or registration errors. For the signal level alignment, only partial signals are available
Xiaoyu Cong, Yubing Han, Weixing Sheng, Shanhong Guo, Hui Sun   +4 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Research on the Compensation Strategy of the Initial Alignment of the SINS Based on the Dynamic Model of the Shearer

IEEE Access, 2019
The strap-down inertial navigation system (SINS) is a commonly used sensor for autonomous underground navigation that can be used for shearer positioning under a coal mine.
Yuming Chen, Wei Li, Hai Yang, Ting Xia
doaj   +1 more source

A two-position initial alignment algorithm based on RLS estimation

Journal of Physics: Conference Series
Abstract In response to the need for an inertial navigation system with a rotation modulation function to achieve accurate alignment in a short time, an alignment method based on recursive least squares (RLS) and using two-position alignment is proposed.
Yuqi Xiao, Xudong Yu, Ding Li, Qixin Lou, Zhi Li   +4 more
openaire   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

Research on an Improved Method for Foot-Mounted Inertial/Magnetometer Pedestrian-Positioning Based on the Adaptive Gradient Descent Algorithm

Sensors, 2018
Foot-mounted Inertial Pedestrian-Positioning Systems (FIPPSs) based on Micro Inertial Measurement Units (MIMUs), have recently attracted widespread attention with the rapid development of MIMUs.
Qiuying Wang, Juan Yin, Aboelmagd Noureldin, Umar Iqbal   +3 more
doaj   +1 more source