Results 181 to 190 of about 27,599,660 (354)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The initial development and validation of a child-oriented food literacy questionnaire. [PDF]

Public Health Nutr
van Lier I, van Belkom B, van Mil E, Havermans R.   +3 more
europepmc   +1 more source

Using a theory-informed approach to guide the initial development of a post-tuberculosis care package in British Columbia, Canada. [PDF]

BMC Health Serv Res, 2023
Romanowski K, Cook VJ, Gilbert M, Johnston JC.   +3 more
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

A bioabsorbable adhesive wrap for sutureless arterial repair: Initial development and preclinical testing in a rat model. [PDF]

J Trauma Acute Care Surg
Nithianandam P, Hesek A, Steinmetz M, Mills J, Liu R, Corao-Uribe D, Shaffer T, Blauvelt DG, Wilmington, Delaware.   +9 more
europepmc   +1 more source

Patient Participation in Forensic Psychiatric Care: The Initial Development and Content Validity of a New Instrument. [PDF]

J Forensic Nurs, 2023
Selvin M, Almqvist K, Fogelkvist M, Lundqvist LO, Schröder A.   +4 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Influence of Light Quality on the Initial Development in Edible Brown Alga <i>Cladosiphon okamuranus</i>. [PDF]

Plants (Basel)
Sato Y, Inomata E, Nagoe H, Numata Y, Tanaka A.   +4 more
europepmc   +1 more source

Initial development and validation of item banks to measure problematic hypersexuality. [PDF]

Open Res Eur, 2023
van Tuijl P, Verboon P, van Lankveld J.
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source