Results 201 to 210 of about 27,599,660 (354)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Initial development of the writing to heal app: A structured writing series for caregivers of spouses living with Alzheimer's disease and related dementias. [PDF]

open access: yesJ Alzheimers Dis
Weiss S   +11 more
europepmc   +1 more source

Local development initiatives

open access: yes, 2015
Demographic trends in the Nordic countries are characterised by urbanisation, mobility and ageing population. Many municipalities and societies – especially those that are distant from large cities – are deeply affected by these changes, and they are facing serious challenges when it comes to issues such as ensuring a population of skilled people and ...
openaire   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Development and Initial Validation of Mindfulness-Based Pain Reduction (MBPR) in Patients With Chronic Low Back Pain

open access: yesJournal of Pain Research
Wolf E Mehling,1,2 Carrie E Brintz,3,4 Wendy Hartogensis,2 Christiane Wolf,5 Kirsten Rogers,2 Shelley R Adler,1,2 Irina A Strigo,6,7 Frederick M Hecht2,8 1Department of Family and Community Medicine, University of California, San Francisco, San Francisco,
Mehling WE   +7 more
doaj  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Initial development of the Stress Monitoring and Response Tool (SMART): A holistic measure of stress following trauma. [PDF]

open access: yesPLoS One
Lowery-Gionta EG   +8 more
europepmc   +1 more source

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