Heterotropic regulation and negative homotropic cooperativity
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
Key biomechanical features of jump-landing under cognitive dual-task conditions: an XGBoost-SHAP-based explainable machine learning analysis. [PDF]
Zhu Y +6 more
europepmc +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
Preventing lower limb injuries in women's football: Influence of the Stop X prevention programme on jump performance and isokinetics in professional and young elite-level female football - a prospective observational cohort study. [PDF]
Seiler J +6 more
europepmc +1 more source
Explicit Predictable Compensators for Single Jump Processes with Initial Information
We study the predictable compensators of stochastic processes in a single jump filtration augmented with initial information represented by a sub-$σ$-algebra $\mathcal{H}$. We consider adapted càdlàg processes of finite variation and give an explicit construction of their predictable compensators.
openaire +2 more sources
The Jump Component of the Volatility Structure of Interest Rate Futures Markets: An International Comparison [PDF]
We propose a generalization of the Shirakawa (1991) model to capture the jump component in fixed income markets. The model is formulated under the Heath, Jarrow and Morton (1992) framework, and allows the presence of a Wiener noise and a finite number of
To, Thuy Duong, Carl Chiarella
core
Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer +7 more
wiley +1 more source
Correction: Neuromuscular adaptations to load-matched isometric vs. dynamic resistance training in Kho-Kho athletes: a pilot investigation. [PDF]
Zhang Z +4 more
europepmc +1 more source
A minimal cellulosome‐like system in Cellulosilyticum lentocellum
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan +2 more
wiley +1 more source
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source

