Results 61 to 70 of about 1,934,975 (307)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

The Stellar Content of NGC 3603 Revisited: Is the IMF Top Heavy?

The Astrophysical Journal
Studies of the resolved stellar populations of young massive clusters have shown that the slope of the initial mass function (IMF) appears to be the same everywhere, with no dependence on stellar density or metallicity.
Philip Massey, Nidia I. Morrell, Kathryn F. Neugent, Monica Herzog, Maria R. Drout, Caitlin O’Brien   +5 more
doaj   +1 more source

Initial mass function of planetesimals formed by the streaming instability [PDF]

, 2016
The streaming instability is a mechanism to concentrate solid particles into overdense filaments that undergo gravitational collapse and form planetesimals.
Urs Schafer, Chao-Chin Yang, A. Johansen
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Constraining the z ∼ 1 Initial Mass Function with HST and JWST Lensed Stars in MACS J0416.1−2403

The Astrophysical Journal
Our understanding of galaxy properties and evolution is contingent on knowing the initial mass function (IMF), and yet to date the IMF is constrained only to local galaxies.
Sung Kei Li, Jose M. Diego, Ashish K. Meena, Jeremy Lim, Leo W. H. Fung, Arsen Levitskiy, James Nianias, Jose M. Palencia, Hayley Williams, Jiashuo Zhang, Alfred Amruth, Thomas J. Broadhurst, WenLei Chen, Alexei V. Filippenko, Patrick L. Kelly, Anton M. Koekemoer, Derek Perera, Bangzheng Sun, Liliya L. R. Williams, Rogier A. Windhorst, Haojin Yan, Adi Zitrin   +21 more
doaj   +1 more source

BANYAN. IX. The Initial Mass Function and Planetary-mass Object Space Density of the TW HYA Association [PDF]

, 2016
A determination of the initial mass function (IMF) of the current, incomplete census of the 10 Myr-old TW Hya association (TWA) is presented. This census is built from a literature compilation supplemented with new spectra and 17 new radial velocities ...
J. Gagn'e, J. Faherty, E. Mamajek, L. Malo, R. Doyon, J. Filippazzo, A. Weinberger, J. Donaldson, S. L'epine, D. Lafrèniere, É. Artigau, A. Burgasser, D. Looper, A. Boucher, Y. Beletsky, Sara Camnasio, Charles Brunette, Geneviève Arboit   +17 more
semanticscholar   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Why is the Star Formation Rate Proportional to Dense Gas Mass?

The Astrophysical Journal
One of the most profound empirical laws of star formation is the Gao–Solomon relation, a linear correlation between the star formation rate (SFR) and the dense molecular gas mass.
Sihan Jiao, Fengwei Xu, Hauyu Baobab Liu, Yuxin Lin, Jingwen Wu, Zhi-Yu Zhang, Zhiqiang Yan, Di Li, Chao-Wei Tsai, Yongkun Zhang, Linjing Feng, Ke Wang, Zheng Zheng, Fanyi Meng, Hao Ruan, Fangyuan Deng, Keyun Su   +16 more
doaj   +1 more source

Comparison of physical characteristics of mass and luminosity function of disk systems in barred and unbarred spiral galaxies

مجلة بغداد للعلوم
Among the most important ways to investigate galaxies' distribution over cosmic time is the luminosity function LF in terms of baryonic disc mass ψS(Mb), magnitude  .
Al Najm M.N., Y. E. Rashed , H. H. AL-Dahlaki   +2 more
doaj   +1 more source