Results 61 to 70 of about 1,589,274 (291)

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

Molecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu, Fenglin Shen, Yang Liu, Ziqing Zhong, Yongling Chen, Zhiyuan Xia, Cuiju Mo, Hongxiu Yu   +7 more
wiley   +1 more source

Early Enrichment Population Theory at High Redshift

The Astrophysical Journal
An early enrichment population (EEP) has been theorized to produce the observed intracluster medium (ICM) metallicity of galaxy clusters. This population likely existed at high redshifts ( z  ∼ 10), relics of which we posit exist today as dwarf galaxies.
Anne E. Blackwell, Joel N. Bregman
doaj   +1 more source

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

MATRIX GREEN’S FUNCTION OF DOUBLE-DIFFUSIVITY PROBLEM AND ITS APPLICATIONS TO PROBLEMS WITH INNER POINT SOURCE

TASK Quarterly, 2019
The matrix Green’s function of the initial-boundary value problem of admixture double-diffusivity is defined. The initial-boundary value problem with a point source is formulated for the matrix elements for determination of the matrix Green’s function ...
YEVHEN CHAPLYA, OLHA CHERNUKHA, YURII BILUSHCHAK   +2 more
doaj   +1 more source

Templates for Fitting Photometry of Ultra-high-redshift Galaxies

The Astrophysical Journal Letters, 2023
Recent data from the James Webb Space Telescope allow a first glimpse of galaxies at z ≳ 11. The most successful tool for identifying ultra-high-redshift candidates and inferring their properties is photometric template fitting.
Charles L. Steinhardt, Vasily Kokorev, Vadim Rusakov, Ethan Garcia, Albert Sneppen   +4 more
doaj   +1 more source

Evidence for primordial mass segregation in globular clusters [PDF]

, 2008
We have studied the dissolution of initially mass segregated and unsegregated star clusters due to two-body relaxation in external tidal fields, using Aarseth's collisional N-body code NBODY4 on GRAPE6 special-purpose computers. When extrapolating results of initially not mass segregated models to globular clusters, we obtain a correlation between the ...
arxiv   +1 more source

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

Molecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti, Shingo Inagaki, Tuyen Thuy Bich Ho, Akihiro Seki, Keiko Yoshida, Kosuke Satomura, Yoshio Sakai, Shuichi Kaneko, Taro Yamashita   +8 more
wiley   +1 more source

The Global Mass Functions of 35 Galactic globular clusters: II. Clues on the Initial Mass Function and Black Hole Retention Fraction [PDF]

, 2017
In this paper we compare the mass function slopes of Galactic globular clusters recently determined by Sollima & Baumgardt (2017) with a set of dedicated N-body simulations of star clusters containing between 65,000 to 200,000 stars. We study clusters starting with a range of initial mass functions (IMFs), black hole retention fractions and orbital ...
arxiv   +1 more source

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

Molecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric, Annika Auranen, Katrin Kleinmanns, René DePont Christensen, Liv Cecilie Vestrheim Thomsen, Cara Ellen Wogsland, Emmet McCormack, Johanna Mäenpää, Kristine Madsen, Karen Stampe Petersson, Mansoor Raza Mirza, Line Bjørge   +11 more
wiley   +1 more source

Do Red Galaxies Form More Stars than Blue Galaxies?

The Astrophysical Journal
A new model is proposed in which typical galaxies form most of their stellar mass in a phase with an intrinsically red stellar population. In the standard picture, galaxies with intrinsically red stellar populations are believed to have old stellar ...
Charles L. Steinhardt
doaj   +1 more source