Results 61 to 70 of about 11,541,392 (252)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A Modified Initial Mass Function of the First Stars with Explodability Theory under Different Enrichment Scenarios

The Astrophysical Journal
The most metal-poor stars record the earliest metal enrichment triggered by Population III stars. By comparing observed abundance patterns with theoretical yields of metal-free stars, physical properties of their first star progenitors can be inferred ...
Ruizheng Jiang, Gang Zhao, Haining Li, Qianfan Xing   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The Initial Mass Function of the Galactic Early-type Field Stars Based on the LAMOST Survey

The Astrophysical Journal
Research on the high-mass end of the initial mass function (IMF) has been limited due to a scarcity of samples. Recently, Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST), as the most efficient spectroscopic telescope, has provided new ...
Qida Li, Jianping Xiong, Zhenwei Li, Dan Qiu, Chao Liu, Zhanwen Han, Xuefei Chen   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Intense Star Cluster Formation: Stellar Masses, the Mass Function, and the Fundamental Mass Scale

The Astrophysical Journal Letters
Within the birth environment of a massive globular cluster, the combination of a luminous young stellar population and a high column density induces a state in which the thermal optical depth and radiation pressure are both appreciable.
Christopher D. Matzner
doaj   +1 more source

Limited imprint of high-mass initial mass function variations on sodium abundances in main sequence galaxies

Astronomy & Astrophysics
Growing evidence suggests that the stellar initial mass function (IMF) varies systematically across galaxies, deviating from the canonical Milky Way form.
Guo Ziyi, Romano Donatella, Yan Zhiqiang, Zhang Zhi-Yu, Fu Xiaoting, Xie Lizhi, Jerabkova Tereza, De Lucia Gabriella, Hirschmann Michaela, Fontanot Fabio, Gjergo Eda, Concas Alice, Tang Xiaodong   +12 more
doaj   +1 more source

The initial mass function in HII galaxies [PDF]

, 1987
Observation of a large sample of HII galaxies shows that the emission line ratios of the youngest objects change systematically with gaseous oxygen abundance, which was interpreted as resulting from changes in the initial mass function (IMF) of the ...
Campbell, Alison W.
core  

The shape of the initial cluster mass function: What it tells us about the local star formation efficiency [PDF]

, 2008
We explore how the expulsion of gas from star cluster forming cloud cores due to supernova explosions affects the shape of the initial cluster mass function, that is, the mass function of star clusters when effects of gas expulsion are over.
Goodwin, S.P., Kroupa, P., Baumgardt, H., Goodwin, S. P., Parmentier, G.   +4 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source