Results 121 to 130 of about 688,518 (313)
KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source
GPS-derived orbits for the GOCE satellite [PDF]
, 2018 The first ESA (European Space Agency) Earth explorer core mission GOCE (Gravity field and steady-state Ocean Circulation Explorer) was launched on 17 March 2009 into a sun-synchronous dusk-dawn orbit with an exceptionally low initial altitude of about ...
Bock, Heike +7 more
core
Binary Neutron-Star Systems: From the Newtonian Regime to the Last Stable Orbit
, 1998 We report on the first calculations of fully relativistic binary circular orbits to span a range of separation distances from the innermost stable circular orbit (ISCO), deeply inside the strong field regime, to a distance ($\sim$ 200 km) where the ...
A. Abramovici +35 more
core +1 more source
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy +12 more
wiley +1 more source
, 2005 We report the discovery of a new low-mass spectroscopic (SB2) stellar binary system in the star-forming region of Upper Scorpius. This object, UScoCTIO5, was discovered by Ardila (2000), who assigned it a spectral class of M4.
Ansgar Reiners +4 more
core +1 more source
Periodic Orbit Scar in Propagation of Wavepacket [PDF]
arXiv, 2017 This study analyzed the scar-like localization in the time-average of a timeevolving wavepacket on the desymmetrized stadium billiard. When a wavepacket is launched along the orbits, it emerges on classical unstable periodic orbits as a scar in the stationary states.
arxiv
Molecular Oncology, EarlyView.Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen +6 more
wiley +1 more source
Clinical heterogeneity in a family with flail arm syndrome and review of hnRNPA1‐related spectrum
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1910-1917, December 2022., 2022 Abstract Objective Flail arm syndrome (FAS) is one of the atypical subtypes of amyotrophic lateral sclerosis (ALS). Mutations in hnRNPA1 encoding heterogeneous nuclear ribonucleoprotein (hnRNP) A1 are a rare genetic cause of ALS. Herein, marked clinical heterogeneity of FAS in a pedigree with a known hnRNPA1 variant was described to raise early ...
Xiaochen Han +5 more
wiley +1 more source
First In-Orbit Results from the UoSAT -12 Minisatellite [PDF]
, 1999 In 1995, having built and launched twelve 50-kg micro satellites, the Surrey Space Centre made a strategic decision to develop and demonstrate a larger low-cost satellite platform.
Sweeting, Martin, Ward, Jeffrey
core +1 more source