Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
DETERMINATION OF INITIAL CONDITIONS FOR SATELLITE FORMATION ELYING IN ELLIPTICAL ORBITS
The initial conditions that generate bounded motion in eccentric reference orbit are determined for satellite formation flying. Because Hill's equations cannot describe the relative motion between two satellites in eccentric orbit, a new relative dynamics utilizing the nonlinearity and eccentricity correction for Hill's initial conditions is ...
Woo-Kyoung Lee +4 more
openaire +3 more sources
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
COSMIC-2 Precise Orbit Determination [PDF]
We present initial results for post-processed GNSS orbit and clock estimation for the FORMOSAT-7/COSMIC-2 (Constellation Observing System for Meteorology, Ionosphere, and Climate) constellation.
Arnold, Daniel +5 more
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Space-Based Orbit Determination Using Passive Optical Measurements in LEO [PDF]
openThe increasing number of artificial objects placed in Low Earth Orbit (LEO) has created the need for improvement in the present Space Surveillance and Tracking (STT) systems, which perform Orbit Determination (OD) to estimate their trajectories ...
CABRERA GARCIA, JUAN FELIPE
core
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Autonomous Orbit Determination of LLO Satellite Using DRO–LLO Links and Lunar Laser Ranging
A stable and high-precision autonomous orbit determination scheme for a Low Lunar Orbit (LLO) spacecraft is proposed, leveraging satellite-to-satellite tracking (SST) measurement data and lunar laser ranging data.
Shixu Chen +4 more
doaj +1 more source

