Results 121 to 130 of about 4,565,671 (287)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

An open Monte Carlo based implementation of Gauss's method for initial orbit determination

Tecnociencia
Hundreds or thousands of Near-Earth Asteroids (NEAs) are discovered every year, so being able to determine their orbits to follow them successfully in the future is essential to warn of the danger they could present. Numerous methods have been developed
José B. Batista-Mendoza , Eduardo Chung , Adam’s Martínez-Soto , Joaquín Fábrega-Polleri , Carlos A. Fernández-Valdés   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A Novel Algorithm for Precise Orbit Determination Using a Single Satellite Laser Ranging System Within a Single Arc for Space Surveillance and Tracking

Aerospace
A satellite laser ranging (SLR) system uses lasers to measure the range from ground stations to space objects with millimeter-level precision. Recent advances in SLR systems have increased their use in space surveillance and tracking (SST).
Dong-Gu Kim, Sang-Young Park, Eunji Lee
doaj   +1 more source

Generalizing Trilateration: Approximate Maximum Likelihood Estimator for Initial Orbit Determination in Low Earth Orbit

IEEE Transactions on Aerospace and Electronic Systems
With the increase in the number of active satellites and space debris in orbit, the problem of initial orbit determination (IOD) becomes increasingly important, demanding a high accuracy. Over the years, different approaches have been presented such as filtering methods (for example, Extended Kalman Filter), differential algebra or solving Lambert's ...
Ricardo Ferreira 0002, Filipa Valdeira, Marta Guimarães, Cláudia Soares   +3 more
openaire   +4 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Probabilistic Initial Orbit Determination using Radar Returns

, 2014
The most complete description of the state of a system at any time is given by knowledge of the probability density function, which describes the locus of possible states conditioned on any available measurement information. When employing radar returns,
Jah, Moriba K., DeMars, Kyle J.
core  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Geocoding of SAR Image Using the Orbit and Attitude Determination of RADARSAT [PDF]

Journal of Astronomy and Space Sciences, 1998
The Synthetic Aperture Radar (SAR) image and the Digital Elevation Model (DEM) of an target area are put into use to generate three dimensional image map. An method of image map generation is explained.
Jin Wook So, Kyu-Hong Choi, Joong-Sun Won   +2 more
doaj