Results 31 to 40 of about 190,348 (307)

Theoretical and Parametric Studies on the Lateral-Resistant Performance of the Steel Grid Shear Wall

Buildings
This study investigates a novel steel grid shear wall (SGSW) structure with lightweight and discrete lateral-resistance members, focusing on its structural behavior in lateral resistance.
Yan Yang, Xiangyu Yan, Zhihua Chen, Yuanhao Wen   +3 more
doaj   +1 more source

Initial bacterial retention on polydimethylsiloxane of various stiffnesses: The relevance of modulus (mis)match

Colloids and Surfaces B: Biointerfaces, 2022
Initial retention of the bacterium Escherichia coli on model poly(dimethylsiloxane) (PDMS) surfaces was studied as a function of substrate bulk and surface mechanical stiffness values. Our reference PDMS system was designed such that out of the parameters that govern bacterial adhesion only the mechanical stiffness was systematically varied.
Drebezghova, Viktoriia, Hakil, Florence, Grimaud, Régis, Gojzewski, Hubert, Vancso, G. Julius, Nardin, Corinne   +5 more
openaire   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Research on Shear Behavior of Sand–Structure Interface Based on Monotonic and Cyclic Tests

Applied Sciences, 2021
In order to study the shear behavior of the interface between sand and structure, a series of shear tests were carried out using an HJ-1 ring shear apparatus (Nanjing, China).
Pei Zhang, Shijia Ding, Kang Fei
doaj   +1 more source

Brachial monomelic amyotrophy as an initial manifestation of stiff person syndrome

Journal of Neurosciences in Rural Practice, 2022
Stiff person syndrome (SPS) is characterized by rigidity of truncal and proximal muscles. The presence of abdominal and paraspinal rigidity is a defining clinical feature of SPS. It is rarely associated with the lower motor neuron (LMN) features. We report a patient with SPS whose initial clinical presentation was that of brachial monomelic amyotrophy (
Ray, Somdattaa, Kamath, Vikram, Rajesh, K. N.   +2 more
openaire   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Effects of the Initial Orientation of Actin Fibers on Global Tensile Properties of Cells

Journal of Biomechanical Science and Engineering, 2010
Tensile tests of a single cell were simulated in order to understand the effects of the initial orientation of actin fibers (AFs) on global tensile properties. The properties examined included cell deformation, stiffness, and AF behavior.
Yoshihiro UJIHARA, Masanori NAKAMURA, Hiroshi MIYAZAKI, Shigeo WADA   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source