Results 1 to 10 of about 1,507,854 (249)
Cytoplasmic chromatin fragments—from mechanisms to therapeutic potential
eLife, 2021 Senescent cells, damaged cells that permanently exit the cell cycle, play important roles in development, tissue homeostasis, and tumorigenesis.
Karl N Miller +4 more
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Targeting FBXO44/SUV39H1 elicits tumor cell-specific DNA replication stress and viral mimicry
Cell Stress, 2021 Repetitive elements (REs) are normally transcriptionally silenced in somatic cells by repressive epigenetic modifications, which are thought to include DNA methylation and histone modifications such as deacetylation, H3K9me3, and H4K20me3.
Jia Z. Shen, Charles Spruck
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IgY Antibodies from Birds: A Review on Affinity and Avidity
Animals, 2023 IgY antibodies are found in the blood and yolk of eggs. Several studies show the feasibility of utilising IgY for immunotherapy and immunodiagnosis. These antibodies have been studied because they fulfil the current needs for reducing, replacing, and ...
Bianca Lisley Barboza Pacheco +2 more
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Radiotherapy in bone sarcoma: the quest for better treatment option
BMC Cancer, 2023 Bone sarcomas are rare tumors representing 0.2% of all cancers. While osteosarcoma and Ewing sarcoma mainly affect children and young adults, chondrosarcoma and chordoma have a preferential incidence in people over the age of 40.
Marie-Anaïs Locquet +3 more
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Accuracy of insulin resistance indices for metabolic syndrome: a cross-sectional study in adults
Diabetology & Metabolic Syndrome, 2018 Background This study aimed to determine the ability of commonly used insulin resistance indices to identify the metabolic syndrome. Methods 183 people referred for outpatient care at the Metabolism Unit of Hospital de Clínicas de Porto Alegre were ...
Luciana Pavan Antoniolli +4 more
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Nature Communications, 2023 Pluripotency is coordinated at multiple levels of gene expression. Here the authors show that ribosome biogenesis is tightly regulated in embryonic stem cells (ESC) to control the translation of transcription and chromatin factors and dictate ESC fate.
Sébastien Durand +18 more
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Machine learning-based detection of label-free cancer stem-like cell fate
Scientific Reports, 2022 The detection of cancer stem-like cells (CSCs) is mainly based on molecular markers or functional tests giving a posteriori results. Therefore label-free and real-time detection of single CSCs remains a difficult challenge.
Alexis J. Chambost +10 more
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A systematic genome-wide mapping of oncogenic mutation selection during CRISPR-Cas9 genome editing
Nature Communications, 2021 CRISPR-Cas9 gene editing can induce a p53 mediated damage response. Here the authors investigate the possibility of selection of pre-existing cancer driver mutations during CRISPR-Cas9 knockout based gene editing and identify KRAS mutants that may confer
Sanju Sinha +12 more
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Frontiers in Oncology, 2018 The importance of epigenetic dysregulation to acute myeloid leukemia (AML) pathophysiology has become increasingly apparent in recent years. Epigenetic regulators, including readers, writers, and erasers, are recurrently dysregulated by way of ...
Younguk Sun +2 more
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Memories and history of Hansen's disease in Brazil told by witnesses (1960-2000) [PDF]
História, Ciências, Saúde: Manguinhos, 2003 This report is a preliminary result of a survey on memories and history of Hansen's disease, or 'hanseniasis', prepared by the Fundação Oswaldo Cruz (Fiocruz) and the Universidade Federal do Rio de Janeiro (UFRJ) using statements from those who have been
Laurinda Rosa Maciel +3 more
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