Can an active outdoor living initiative in kindergartens in two disadvantaged neighbourhoods increase physical activity among children? Findings from a within-subject design of the Happy Healthy Active Children initiative. [PDF]
BMJ OpenMüllertz ALO +5 more
europepmc +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Equipping pharmacists to improve osteoporosis management for aged care residents: a pilot study. [PDF]
J Pharm Policy PractLaird C, Williams KA, Benson H.
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The Permanent Editioral Board: Aviators Code Initiative [PDF]
he Permanent Editorial Board (PEB) provides editorial oversight and stewardship of the Aviators Code Initiative (ACI) and implementation of the family of codes of conduct and supporting ...
Aviators Code Initiative
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Inclusive Initiatives in Health Professions Education: A Journal-Led Peer Reviewer Development Initiative. [PDF]
Clin TeachQuaye B +3 more
europepmc +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Childhood adversity and social anxiety among college students: the mediating roles of personal growth initiative and problematic social media use. [PDF]
Front PsycholLi Y, Zhao S, Qiu Y, Pi L.
europepmc +1 more source