Results 91 to 100 of about 91,497 (309)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Infections with spore-forming bacteria in persons who inject drugs, 2000-2009. [PDF]

, 2013
Since 2000 in the United Kingdom, infections caused by spore-forming bacteria have been associated with increasing illness and death among persons who inject drugs (PWID).
White, JM, Goldberg, DJ, Ramsay, CN, Goldberg, David, Ramsay, Colin N, Marongiu, A, Roy, Kirsty, Hope, Vivian D, Kirsty Roy, Hope, Vivian D., Hope, VD, David J. Goldberg, Palmateer, NE, Roy, K, Palmateer, Norah E.; id_orcid, Andrea Marongiu, Norah E. Palmateer, Goldberg, David J, Joanne M. White, White, Joanne M., Grant, Kathie A., Colin N. Ramsay, Grant, Kathie A, Grant, KA, Fortune Ncube, Ncube, F, White, Joanne M, Ncube, Fortune, Kathie A. Grant, Marongiu, Andrea, Ramsay, Colin N., Vivian D. Hope, Palmateer, Norah E   +32 more
core   +1 more source

Childhood misbehavior and the risk of injecting drug use

Drug and Alcohol Dependence, 1997
This investigation examined the association between misbehavior in early life and subsequent injecting drug use (IDU) among Baltimore participants in the NIMH Epidemiologic Catchment Area study. Information about early misbehavior was collected in 1981 and about IDU in 1994-1996.
Y D, Neumark, J C, Anthony
openaire   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

“Just not all ice users do that”: investigating perceptions and potential harms of Australia’s Ice Destroys Lives campaign in two studies

Harm Reduction Journal, 2017
Background In 2015, the Australian government launched the media campaign Ice Destroys Lives targeting crystal methamphetamine use. Previous research indicates mass media campaigns may have harmful effects for people engaged in drug use.
Caitlin H. Douglass, Elizabeth C. Early, Cassandra J. C. Wright, Anna Palmer, Peter Higgs, Brendan Quinn, Paul M. Dietze, Megan S. C. Lim   +7 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Trends in property and illicit drug crime around the Medically Supervised Injecting Centre in Kings Cross: 2012 update [PDF]

, 2013
Aim: The Medically Supervised Injecting Centre (MSIC) opened in Kings Cross in May 2001. This paper examines whether there have been: (i) increases in the volume of robbery, theft and illicit drug offences in Kings Cross Local Area Command (LAC) up until
Nicole Mahoney, Neil Donnelly
core  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Injecting risk behaviours, self-reported mental health and crime [PDF]

, 2013
This paper explores differences between two types of illicit drug users (heroin users and non-heroin users) in relation to injecting risk behaviours, self-reported mental health, driving and crime.Key findingsParticipants were divided into two groups ...
Jennifer Stafford, Lucy Burns
core