Results 81 to 90 of about 176,131 (302)

Injecting drug abuse: Survival after intensive care admission and forensic toxicology reports at death [PDF]

, 2014
Efst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinnInngangur: Notkun vímuefna í æð er alþjóðlegt vandamál sem hefur alvarlegar afleiðingar fyrir neytandann og samfélagið í heild.
Jakob Kristinsson, Kristinn Sigvaldason, Sigurbergur Kárason, Svava Þórðardóttir, Þóroddur Ingvarsson   +4 more
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The Long-Term Effectiveness of Methadone Maintenance Treatment in Prevention of Hepatitis C Virus Among Illicit Drug Users : A Modeling Study [PDF]

, 2014
Article Accepted Date: Oct 7, 2013 Acknowledgments: We would like to thank all MMT centers' staff in Shiraz for their cooperation in this study. Funding Support: This study was funded and supported by the Tehran University of Medical Sciences.Peer ...
Javanbakht, Mehdi, Mashayekhi, Atefeh, Mirahmadizadeh, Alireza   +2 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Needle exchange provision in Ireland: The context, current levels of service provision and recommendations. A joint report by the National Drugs Strategy Team and the National Advisory Committee on Drugs. [PDF]

, 2008
This document emerged out of concerns from the Voluntary Drug Sector about the need for additional needle exchange services to match the increases in injecting drug use nationally.
Cox, Gemma, Robinson, Janet
core  

Decrease in health-related quality of life associated with awareness of hepatitis C virus infection among people who inject drugs in Scotland [PDF]

, 2013
Chronic hepatitis C virus (HCV) infection can significantly reduce health-related quality of life (QoL), but it is not clear if reduction is associated with the infection or with being aware of one's infection status.
Allen, Elizabeth, Cameron, Sheila O., David J., Goldberg, Hutchinson, Sharon, McDonald, Scott, Palmateer, Norah Elizabeth, Taylor, Avril   +6 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Bridging the data gaps in the epidemiology of hepatitis C virus infection in Malaysia using multi-parameter evidence synthesis [PDF]

, 2014
BACKGROUND: Collecting adequate information on key epidemiological indicators is a prerequisite to informing a public health response to reduce the impact of hepatitis C virus (HCV) infection in Malaysia.
A Goubar, A Thomas, Adeeba Kamarulzaman, AM Presanis, B Vicknasingam, B Vicknasingam, CS Graham, CW Shepard, D De Angelis, D Lunn, DL Thomas, G Duraisamy, GJ Dore, H Vrielink, Herlianna Naning, HJ Bakar Bin, JE Wang, JM Micallef, K Kavanagh, K Mohd Hanafiah, M Sinniah, M Sweeting, M Winslow, Maznah Dahlui, MC Chawarski, MN Haslina, N Mohamed, P Luksamijarulkul, RJ Harris, RL Suresh, Rosmawati Mohamed, S Tan, SA McDonald, Scott A McDonald, W Sievert   +34 more
core   +2 more sources