Results 41 to 50 of about 2,485,273 (247)

CAE for Advanced Injection Molding Technologies

, 2019
Injection molding is one of the most popular polymer processing methods and has been used to mass produce plastics products for many decades. However, due to increasingly stringent requirements and higher customer expectations, conventional injection ...
Chang, Rong-Yeu;Huang, Chao-Tsai (CT)
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Modeling fluid injection into a porous spherical composite with anisotropy [PDF]

Известия Саратовского университета. Новая серия: Математика. Механика. Информатика
Porous spherical composites are widely found both in natural objects and in technical applications. To describe the mechanical behavior of such structures, it is necessary to take into account the interaction of solid and fluid phases, since the fluid ...
Kucherenko, Denis V.
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Evaluation of postoperative complications of hypospadias using high-frequency ultrasound imaging

BMC Urology
Purpose Various complications following hypospadias surgery present distinct manifestations when examined with ultrasound. Utilizing high-frequency ultrasound, clinicians can promptly identify these complications and initiate appropriate treatment.
Jun Zhuang, Xueshang Su, Ying Jia, Qiaoyuan Zheng, Qingqian Wei, Ziming Zhang, Jintian Hu, Li Yuan, Hongli Chai   +8 more
doaj   +1 more source

Factors Influencing Litigation Compensation in Plastic Surgery: A Retrospective Analysis in China

Plastic and Reconstructive Surgery, Global Open
Background:. Doctor–patient disputes have become a prominent problem in contemporary society. The analysis and discussion of the factors leading to litigation compensation are essential to prevent and resolve doctor–patient conflicts, reduce litigation ...
Xueshang Su, MD, Yutong Liang, MD, Jun Zhuang, MD, Qingqian Wei, MD, Ziming Zhang, MD, Xue Ouyang, MD, Haixia Jiang, MD, Na Cai, MD, Jintian Hu, MD, Bo Ding, MD   +9 more
doaj   +1 more source

EXFI: a low cost Fault Injection System for embedded Microprocessor-based Boards [PDF]

, 1998
Evaluating the faulty behavior of low-cost embedded microprocessor-based boards is an increasingly important issue, due to their adoption in many safety critical systems. The architecture of a complete Fault Injection environment is proposed, integrating
SONZA REORDA, Matteo, A. Benso, P. Prinetto, Rebaudengo, Maurizio, Sonza Rreorda, M., M. Sonza Reorda, M. Rebaudengo, Benso, Alfredo, Prinetto, Paolo Ernesto   +8 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source