Results 51 to 60 of about 2,272,899 (317)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Modeling fluid injection into a porous spherical composite with anisotropy [PDF]

Известия Саратовского университета. Новая серия: Математика. Механика. Информатика
Porous spherical composites are widely found both in natural objects and in technical applications. To describe the mechanical behavior of such structures, it is necessary to take into account the interaction of solid and fluid phases, since the fluid ...
Kucherenko, Denis V.
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Injective and non-injective realizations with symmetry

Contributions to Discrete Mathematics, 2010
In this paper, we introduce a natural classification of bar and joint frameworks that possess symmetry. This classification establishes the mathematical foundation for extending a variety of results in rigidity, as well as infinitesimal or static rigidity, to frameworks that are realized with certain symmetries and whose joints may or may not be ...
openaire   +2 more sources

Evaluation of postoperative complications of hypospadias using high-frequency ultrasound imaging

BMC Urology
Purpose Various complications following hypospadias surgery present distinct manifestations when examined with ultrasound. Utilizing high-frequency ultrasound, clinicians can promptly identify these complications and initiate appropriate treatment.
Jun Zhuang, Xueshang Su, Ying Jia, Qiaoyuan Zheng, Qingqian Wei, Ziming Zhang, Jintian Hu, Li Yuan, Hongli Chai   +8 more
doaj   +1 more source

Factors Influencing Litigation Compensation in Plastic Surgery: A Retrospective Analysis in China

Plastic and Reconstructive Surgery, Global Open
Background:. Doctor–patient disputes have become a prominent problem in contemporary society. The analysis and discussion of the factors leading to litigation compensation are essential to prevent and resolve doctor–patient conflicts, reduce litigation ...
Xueshang Su, MD, Yutong Liang, MD, Jun Zhuang, MD, Qingqian Wei, MD, Ziming Zhang, MD, Xue Ouyang, MD, Haixia Jiang, MD, Na Cai, MD, Jintian Hu, MD, Bo Ding, MD   +9 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Acoustic monitoring of engine fuel injection based on adaptive filtering techniques [PDF]

, 2010
Diesel engines injection process is essential for optimum operation to maintain the design power and torque requirements and to satisfy stricter emissions legislations. In general this process is highly dependent upon the injection pump and fuel injector
Gu, Fengshou, A. Starr, Ball, Andrew, Ball, A. D., Starr, Andrew G., Albarbar, A., Gu, F., A.D. Ball, A. Albarbar, Starr, A., F. Gu, Ball, A.D.   +11 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source