Results 61 to 70 of about 2,485,273 (247)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Entesopathy of the lateral epicondyle of the humeral bone – current treatment options

Journal of Education, Health and Sport, 2020
Chronic pain located on the lateral surface of the elbow in the area of the lateral epicondyle of the humerus is characteristic for a disease called tennis elbow, which belongs to the group of enthesopathies, i. e.
Kamil Fatyga, Marta Tarczyńska, Krzysztof Gawęda, Rafał Mazur, Łukasz Głodek   +4 more
doaj   +1 more source

Optimisation of Continuous and Pulsed Cooling in Injection Moulding Processes [PDF]

, 2007
The concept of pulsed cooling in injection moulding involves cycling the flow of coolant in order that cooling only takes place as and when it is required, as opposed to continuous cooling, where the coolant in run through the channels throughout the ...
B. A. McCalla, McCalla, B.A., Hornsby, Peter, Wrobel, L.C., Smith, AG, McCalla, BA, Smith, A.G., Allan, PS, P. S. Allan, Wrobel, LC, Allan, P.S., L. C. Wrobel, P. R. Hornsby, Hornsby, PR, A. G. Smith   +14 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Clinical Translation Challenges and Strategies for Tumour Vaccines Considering Multiple Delivery Routes

Vaccines
Background: The high incidence and mortality rates of cancer have kept it at the top of the research agenda for the global healthcare industry, as well as put serious economic pressure on families and society.
Ruiyun Song, Xiao Li, Junsong Zhu, Jian He, Jintong Na   +4 more
doaj   +1 more source

EFFECT OF INOCLATION LOCAL AND COMMERCIAL CHICKEN EGGS WITH ARGININE AMINO ACID ON THE DEVELOPMENT OF BURSA OF FABRICIUS [PDF]

Basrah Journal of Veterinary Research
The present study emphasizes the importance of in Ovo feeding strategies, particularly the supplementation of fertilized eggs with amino acids such as L-arginine to enhance the Bursa of Fabricius development.
Shangaberry Aziz, Questan Ameen, Nasrin Aziz, Ahmed Shaker, Mohammed Mohammed, Adel Hussen   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Efficacy and Safety of Polycaprolactone Filler in Nonsurgical Rhinoplasty: A Pilot Study

Clinical, Cosmetic and Investigational Dermatology
Hailong Huang,1 Huabin Zhang,1 Juhua Jin2 1Department of Injection, ShenZhen Mylike Aesthetic Medicine Hospital, Shenzhen, Guangdong, 518031, People’s Republic of China; 2Department of Cosmetology & Dermatology, ShenZhen Mylike Aesthetic Medicine ...
Huang H, Zhang H, Jin J
doaj  

Evidence and information for national injection safety policies [PDF]

, 2003
The adverse consequences of poor injection practices have been reported for a few decades. However, key elements of evidence and information were lacking to allow decision-makers to formulate policies for the safe and appropriate use of injections.
Hutin, Yvan
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source