Results 61 to 70 of about 1,023,747 (301)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

A qualitative study of persons who inject drugs but who have never helped others with first injections: how their views on helping contrast with the views of persons who have helped with first injections, and implications for interventions

Harm Reduction Journal, 2018
Background Transitioning from non-injection to injection drug use dramatically escalates health risks. Evidence suggests that people who inject drugs (PWID) help in a majority of others’ first injections, yet these helpers represent only a minority of ...
David M. Barnes, Don C. Des Jarlais, Margaret Wolff, Jonathan Feelemyer, Susan Tross   +4 more
doaj   +1 more source

Elevated troponin level as a predictor of inpatient mortality in patients with infective endocarditis in the Southeast United States

BMC Infectious Diseases, 2020
Background Despite recent improvement in management, infective endocarditis (IE) continues to be associated with considerable risk of morbidity and mortality.
William Lorson, Michael P. Veve, Eric Heidel, Mahmoud A. Shorman   +3 more
doaj   +1 more source

Drug use problems with self-injected low-molecular-weight heparins in primary care [PDF]

, 2018
Purpose: Outpatient subcutaneous therapies are becoming increasingly common. A literature search failed to find produced any studies on application problems pertaining to the self-injection of low-molecular-weight heparins (LMWH) in a heterogeneous ...
Hersberger, Kurt, Lampert, Markus, Mengiardi, Seraina, Tsakiris, Dimitrios   +3 more
core  

Non-injection Drug Use and Injection Initiation Assistance among People Who Inject Drugs in Tijuana, Mexico [PDF]

Journal of Urban Health, 2017
Although most people who inject drugs (PWID) report receiving assistance during injection initiation events, little research has focused on risk factors among PWID for providing injection initiation assistance. We therefore sought to determine the influence of non-injection drug use among PWID on their risk to initiate others.
Ben Hamida, Amen, Rafful, Claudia, Jain, Sonia, Sun, Shelly, Gonzalez-Zuniga, Patricia, Rangel, Gudelia, Strathdee, Steffanie A, Werb, Dan   +7 more
openaire   +4 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Low prevalence of hepatitis C co-infection in recently HIV-infected minority men who have sex with men in Los Angeles: a cross-sectional study. [PDF]

, 2015
BackgroundGeographic and sociodemographic characterization of hepatitis C virus (HCV) transmission amongst men who have sex with men (MSM) has been limited.
Bhattacharya, Debika, Blum, Martha L, Bolan, Robert, Bornfleth, Lorelei D, Chew, Kara W, Clare, Laurel E, Gorbach, Pamina M, Javanbakht, Marjan   +7 more
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Wound Botulism in Injection Drug Users: Time to Antitoxin Correlates with Intensive Care Unit Length of Stay

Western Journal of Emergency Medicine, 2009
Objectives: We sought to identify factors associated with need for mechanical ventilation (MV), length of intensive care unit (ICU) stay, length of hospital stay, and poor outcome in injection drug users (IDUs) with wound botulism (WB).Methods: This is a
Offerman, Steven R, Schaefer, Melissa, Thundiyil, Joseph, Cook, Matthew D, Holmes, James F   +4 more
doaj  

Yeast fungaemia among injection drug users in France (2012–2022): a cross-sectional observational studyResearch in context

The Lancet Regional Health. Europe
Summary: Background: Intravenous injection drug use (IVDU) is an established but infrequent risk factor for yeast fungaemia. We aimed to identify features and outcomes of yeast fungaemia associated with IVDU in a nationwide surveillance network in ...
Olivier Paccoud, Olivier Lortholary, Sebastien Imbert, Valerie Letscher-Bru, Karine Boukris-Sitbon, Thomas Obadia, Frederic Dalle, Lilia Hasseine, Florent Morio, Antoine Huguenin, Philippe Poirier, Loic Favennec, Julie Bonhomme, Alexandre Alanio, Fanny Lanternier, Marie Desnos-Ollivier, Taieb Chouaki, Marc Pihet, Anne-Pauline Bellanger, Magalie Demar, Nicole Desbois-Nogard, Muriel Nicolas, Marie-Fleur Durieux, Milène Sasso, Estelle Perraud-Cateau, Jean-Pierre Gangneux, Caroline Mahinc, Sophie Cassaing, Adelaide Chesnay, Guillaume Desoubeaux, André Paugam, Elisabeth Chachaty, Marie-Elisabteth Bougnoux, Lilia Merabet, Patricia Mariani, Maité Micaelo   +35 more
doaj   +1 more source