Results 111 to 120 of about 836,803 (303)

Evaluation of Novel Imidazotetrazine Analogues Designed to Overcome Temozolomide Resistance and Glioblastoma Regrowth

, 2014
The cellular responses to two new temozolomide (TMZ) analogues, DP68 and DP86, acting against glioblastoma multi- forme (GBM) cell lines and primary culture models are reported.
Wheelhouse, Richard T., Wheelhouse, Richard T, Gynther, M., Rautio, J., Rautio, Jarkko, Ramirez, Yulian P, Mladek, Ann C, Sakaria, Jann N, Phillips, Roger M., Ross, Alonso H, Ramirez, Y.P., Mladek, A.C., Phillips, Roger M, Ross, A.H., Gynther, Mikko, Sakaria, J.N.   +15 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Determination of maximum neutral point current injection limits in a three-phase neutral-point-clamped converter

, 2020
The neutral-point-clamped (NPC) converter is nowadays widely used in the industry. The main features of the NPC converter are: (1) The high quality ac voltages that the converter can produce thanks to its capability to generate three voltage levels at ...
Jiang, Zhuolin
core  

Improved Corticosteroid Treatment of Recalcitrant de Quervain Tenosynovitis With a Novel 4-Point Injection Technique

, 2010
Background: Previously described corticosteroid injection techniques for de Quervain tenosynovitis (DQT) refer to either 1-point or 2-point injection techniques, showing superiority of the latter.
Panagiotis Givissis, Thomas Pagonis, Paraskevi Toli, Konstantinos Ditsios, Anastasios Christodoulou   +4 more
core   +1 more source

Effect of inhalation aromatherapy on pain, anxiety, comfort, and cortisol levels during trigger point injection

, 2020
*Sayın Kasar, Kadriye ( Aksaray, Yazar )The objective of this study was to examine the effects of inhaler aromatherapy on the level of pain, comfort, anxiety, and cortisol during trigger point injection in individuals with myofascial pain syndrome ...
Meltem Uyar, Atay, Sevcan, Kuzeyli Yıldırım, Yasemin, Sevcan Atay, Fisun Senuzun Aykar, Kasar, Kadriye Sayin, Yildirim, Yasemin, Kadriye Sayin Kasar, Girgin Sağın, Ferhan, Yasemin Yildirim, Şenuzun Aykar, Fisun, Uyar, Meltem, Ferhan Girgin Sagin, Sagin, Ferhan Girgin, Sayın Kasar, Kadriye   +14 more
core   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Study of fuel injection and mixture formation for a gasoline direct injection engine

, 2005
Future requirements for lower automotive emissions have lead to the development of new internal combustion (IC) engine technologies. Gasoline Direct Injection (GDI), for example, is one of these promising new IC engine concepts.
Reveille, T.
core  

Pneumothorax after trigger point injection: A case report and review of literature

, 2016
BACKGROUND: Myofascial pain syndrome is defined as "pain and/or autonomic phenomena referred from active myofascial trigger points". Trigger point injection is an effective treatment option, which is widely used to treat myofascial pain.
Ahiskalioglu, Elif Oral, Aksoy, Mehmet, Ahıskalıoğlu, Ali, Çelik, Mine, Dostbil, Ayşenur, Alici, Haci Ahmet   +5 more
core   +1 more source