Results 71 to 80 of about 8,725,002 (325)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Study on the Treatment of Urine Retention with Acu - point Injection after Rectocolonic Operation

Huli yanjiu, 1996
肛肠术后患者常出现尿潴留。笔者自1991年～1994年运用中医传统疗法即穴位注射法，对80例肛肠术后尿潴留患者行两侧足三里穴注射甲基硫酸新斯的明注射液，取得良好效果，现报告如下。
李连岁
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Injection scheme with deflecting cavity for a fourth-generation storage ring

Physical Review Accelerators and Beams, 2019
We suggest a new on-axis injection scheme that uses a transverse deflecting rf cavity to kick the incoming beam into an already populated bucket but with a timing offset from the synchronous phase.
J. Kim, G. Jang, M. Yoon, B-H. Oh, J. Lee, J. Ko, Y. Parc, T. Ha, D. Kim, S. Kim, S. Shin   +10 more
doaj   +1 more source

Point-source scalar turbulence [PDF]

, 2007
The statistics of a passive scalar randomly emitted from a point source is investigated analytically. Our attention has been focused on the two-point equal-time scalar correlation function.
ANDREA MAZZINO, ANTONIO CELANI, Basu, Celani, Donsker, Furutsu, MARCO MARTINS AFONSO, Martins fonso, Martins fonso, Novikov   +9 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

The Effect of Intradermal Injection with Two Different Injection Techniques on Pain and Functional Status in Patients with Chronic Nonspecific Neck Pain

Medeniyet Medical Journal
Objective: This study aimed to compare the effectiveness of different mesotherapy techniques applied at various dermal depths on pain, functional status, and quality of life in patients with non-specific neck pain.
Sadiye MURAT
doaj   +1 more source

Experimental study on effect of N2 on physical parameters and phase equilibrium patterns of CO2-rich injection gas [PDF]

Youqicang pingjia yu kaifa
The high cost of industrial flue gas treatment makes injecting CO₂-rich exhaust gas into depleted oil and gas reservoirs a potential technology for enhanced recovery and carbon sequestration. This study aims to guide the injection process, and the effect
QIN Nan, GAN Xiaofei, LUO Yu, LIU Xiaoxu, WEN Bin, CHEN Xingyu
doaj   +1 more source