Results 71 to 80 of about 6,150,128 (285)

Numerical Investigation of the Influence of Injection Scheme on the Ethylene Supersonic Combustion

Advances in Mechanical Engineering, 2014
Ethylene supersonic combustion flow field in different injection schemes was studied numerically in the flight Mach 4. The results show that injection pressure has significant influence on the location of the separation zone and the heat release region ...
Hao Ouyang, Weidong Liu, Mingbo Sun
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Three-point Method Nerve Block for Relieving Pain of Microbotox Injection in Middle and Upper Face

Plastic and Reconstructive Surgery, Global Open
Background:. With the popularity of microbotox, pain caused by multiple microdroplets and subcutaneous injection of botulinum toxin is increasing. This study presents a new, refined, three-point nerve block technique that provides effective pain relief ...
Bing Liu, MD, Xueshang Su, MM, Hongli Chai, MM, Qi Chen, BM, Jintian Hu, MD, Yongqian Wang, MD   +5 more
doaj   +1 more source

Targeted Collection of Plasmid DNA in Large and Growing Animal Muscles 6 Weeks after DNA Vaccination with and without Electroporation

Journal of Immunology Research, 2015
DNA vaccination has been developed in the last two decades in human and animal species as a promising alternative to conventional vaccination. It consists in the injection, in the muscle, for example, of plasmid DNA encoding the vaccinating polypeptide ...
Daniel Dory, Vincent Le Moigne, Roland Cariolet, Véronique Béven, André Keranflec’h, André Jestin   +5 more
doaj   +1 more source

FPGA-based fault injection design for 16K-point FFT processor

The Journal of Engineering, 2019
There are a number of satellites working in the harsh space environment. The charged particles in space may strike the electron devices causing the undesired influences, such as soft errors in memory devices or permanent damage in hardware circuits ...
Chuang-An Mao, Yu Xie, Xin Wei, Yi-Zhuang Xie, He Chen   +4 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

A New Characterization Method for Dynamic Connectivity Field Between Injection and Production Wells in Offshore Reservoir

Journal of Marine Science and Engineering
Connectivity between injection and production wells is critical for efficient oil production, especially in offshore reservoirs where the number of wells is limited.
Changchun Guo, Yuzhou Hu, Li Tao, Mengna Cheng, Fankun Meng, Hui Zhao, Fengshuang Du   +6 more
doaj   +1 more source

Weakly pointed trees and partial injections

Journal of Symbolic Logic, 2008
AbstractWe define the notion of a weakly pointed tree, and characterize the amount of genericity necessary to prevent a uniformly branching tree being weakly pointed. We use these ideas to show there is no topological analogue of a measure-theoretic selection theorem of Graf and Mauldin.
openaire   +4 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source