Results 81 to 90 of about 6,150,128 (285)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Characterizing the vertical variations of hydraulic conductivity of an unconsolidated aquifer based on the direct-push point-source injection tests

Shuiwen dizhi gongcheng dizhi
Hydraulic conductivity (K) and its spatial variability are critical factors governing groundwater flow and solute transport processes. Traditional methods, such as pumping tests and slug tests, often treat the aquifers as homogeneous to derive equivalent
Zhanfeng ZHAO, Xianfang SONG
doaj   +1 more source

Single-point versus double-point injection technique of ultrasound-guided supraclavicular block: A randomized controlled study

Journal of Anaesthesiology Clinical Pharmacology, 2019
Background and Aims: This study aims to compare the single-point injection and double-point injection technique of ultrasound-guided supraclavicular block with regard to the success rate, time taken to perform the procedure, onset and duration of sensory
Nitin Choudhary, Abhijit Kumar, Amit Kohli, Sonia Wadhawan, Tabish H Siddiqui, Poonam Bhadoria, Hemlata Kamat   +6 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

EXFI: a low cost Fault Injection System for embedded Microprocessor-based Boards [PDF]

, 1998
Evaluating the faulty behavior of low-cost embedded microprocessor-based boards is an increasingly important issue, due to their adoption in many safety critical systems. The architecture of a complete Fault Injection environment is proposed, integrating
SONZA REORDA, Matteo, A. Benso, P. Prinetto, Rebaudengo, Maurizio, Sonza Rreorda, M., M. Sonza Reorda, M. Rebaudengo, Benso, Alfredo, Prinetto, Paolo Ernesto   +8 more
core   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Evaluation of methylene blue solution distribution in the four-point transversus abdominis plane block technique in pigs: a pilot anatomical study

Frontiers in Veterinary Science
AimThis prospective pilot anatomical study aimed to develop an ultrasound-guided transversus abdominis plane (TAP) block technique that desensitises cranial and mid-abdominal wall in grower pigs.
Jerneja Sredenšek, Jana Brankovič, Urša Lampreht Tratar, Urša Lampreht Tratar, Maja Čemažar, Maja Čemažar, Mihajlo Đokić, Mihajlo Đokić, Alenka Seliškar   +8 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Myositis ossificans of the elbow after a trigger point injection.

, 2021
Trigger point injection is a simple procedure that is widely performed for relieving pain. Even though there are several complications of trigger point injection, myositis ossificans has not been documented as one of its complications.
신상진
core   +1 more source