Results 71 to 80 of about 1,110,256 (312)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Optimization of injection molding parameter of ti-6al-4v powder mix with palm stearin and polyethylene for the highest green strength by using taguchi method [PDF]

, 2011
This paper present the Taguchi method of L27 (313) orthogonal array as a tool in optimization of Metal injection molding (MIM) parameters for the highest green strength. Injection pressure, injection temperature, powder loading, mold temperature, holding
Ibrahim, M. H. I., Jamaladin, Khairur Rijal, M. Nor, N. H., Muhamad, N., Ruzi, M.   +4 more
core  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

The Effect of Injection-Valve Opening Pressure on Spray-Tip Penetration [PDF]

The effect of various injection-valve opening pressures on the spray-tip penetration was determined for several injection pressure. A common-rail fuel injection system was used.
Marsh, E T, Rothrock, A M
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Performance–Emission Trade‐Offs in RCCI Engines Using High‐Viscosity Alcohol–Diesel Blends Under Variable Injection Pressures

Engineering Reports
This study experimentally investigates the performance, combustion, and emission characteristics of a Reactivity‐Controlled Compression Ignition (RCCI) engine fueled with diesel and the high‐viscosity oxygenated alcohol 2‐Methyl‐1‐butanol.
S. M. Ferdous Azam, Dipak Patel, Ripendeep Singh, Sikata Samantaray, Aravindan M. K., Nivin Joy Thykattusserry, Jasgurpreet Singh Chohan, Yashwant Singh Bisht, Abhijit Bhowmik, Yalew Tamene   +9 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Planar Solid‐State Nanopores Toward Scalable Nanofluidic Integration Based on CMOS Technology

Advanced Engineering Materials, EarlyView.
We present a scalable silicon‐based fabrication strategy for planar solid‐state nanopores to enable their integration with complex nanofluidic systems. Prototype devices demonstrate normal voltage‐current characteristics, good noise performance, and appreciable streaming currents. Our CMOS‐compatible fabrication process offers precise geometric control
Ngan Hoang Pham, Chenyu Wen, Mohammad Hadi Khaksaran, Won‐Yong Lee, Javier Cruz, Klas Hjort, Dongping Wu, Shi‐Li Zhang   +7 more
wiley   +1 more source

Quality prediction of semi-solid die casting of aluminum alloy in terms of machine learning [PDF]

Advanced Manufacturing
Semi-solid die casting of aluminum alloy has been successfully employed to manufacture high-performance components with precise net shapes. However, the quality of these components is highly susceptible to variations in both environmental conditions and ...
Zhiyuan Wang, Xiaogang Hu, Gan Li, Zhen Xu, Hongxing Lu, Qiang Zhu   +5 more
doaj   +1 more source