Results 51 to 60 of about 554,979 (316)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
AtmosphereWith the increasingly prominent environmental and energy issues, emission regulations are becoming more stringent. Ammonia diesel dual fuel (ADDF) engine is one of the effective ways to reduce carbon emissions.
Zhenbin Chen +3 more
doaj +1 more source
Energy Science & Engineering, 2023 The effects of injection pressure and ambient pressure on biodiesel spray characteristics were studied by coupling the in‐nozzle flow, and a constant‐volume combustion bomb experimental platform was built to verify the accuracy of the coupled numerical ...
Zhijiang Ni +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Micropumps actuated negative pressure injection for microchip electrophoresis
, 2008 A simple negative pressure pinched sample injection method was presented. This method combined diaphragm micropumps and a single voltage supply to generate controllable well-defined sample plug, and led to effective electrophoresis separation.
林炳承 +5 more
core +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
NOx Emission Prediction Based on Measurement of in-Cylinder Pressure for CI Engine Running with Diesel and Biodiesel [PDF]
, 2014 NOx is one of the major toxic emissions that needs to be regulated stringently in both EU and USA emission regulations. The engine designer is keen to get an accurate, reliable and cost effective NOx measurement system.
Gu, Fengshou +4 more
core
The Short-Term Effect of Intravitreal Bevacizumab Injection on Intraocular Pressure
, 2014 Objectives: To evaluate the short-term intraocular pressure (IOP) changes after intravitreal injection of 0.05 mL (1.25 mg) bevacizumab. Materials and Methods: The study included 57 eyes of 57 patients who had an intravitreal injection of 0.05 mL ...
Pelin Yılmazbaş +3 more
core +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source