Results 41 to 50 of about 505,676 (266)

A Review of Early Injection Strategy in Premixed Combustion Engines

Applied Sciences, 2019
Due to the increasing awareness of environmental protection, limitations on exhaust emissions of diesel engines have become increasingly stringent. This challenges diesel engine manufacturers to find a new balance between engine performance and emissions.
Xingyu Liang, Zhiwei Zheng, Hongsheng Zhang, Yuesen Wang, Hanzhengnan Yu   +4 more
doaj   +1 more source

Injection Flow Rate Threshold Preventing Atypical In-Cavity Pressure during Low-Pressure Powder Injection Molding

Powders, 2023
Controlling injection parameters is paramount when it comes to producing high-quality green parts using powder injection molding. This work combines experimental and numerical approaches to study the impact of injection parameters on mold in-cavity ...
Francis Arès, Dorian Delbergue, Vincent Demers   +2 more
doaj   +1 more source

Impact of dye injection on intracoronary pressure [PDF]

EuroIntervention, 2009
Coronary angiography is widely used to estimate coronary blood flow velocity, as in the TIMI frame count method. However, it is unknown to what extent the injection of dye elevates intracoronary pressure which may accelerate coronary blood flow velocity.
Stoel, Martin, Kandhai-Ragunath, Jasveen, van Houwelingen, Gert, von Birgelen, Clemens   +3 more
openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Artificial neural networks model for predicting the behavior of different injection pressure characteristics powered by blend of biofuel‐nano emulsion

Energy Science & Engineering, 2022
This investigation deals with the usage of graphene oxide (GO) nanoparticles with orange peel biodiesel in a conventional CI engine. The different fuel blends used for this experiment are biodiesel 10% + diesel 80% + ethanol 5% + surfactant 5% + GO 50 ...
P. V. Elumalai, R. Krishna Moorthy, M. Parthasarathy, Olusegun David Samuel, Hilary I. Owamah, C Ahamed Saleel, Christopher C. Enweremadu, M. Sreenivasa Reddy, Asif Afzal   +8 more
doaj   +1 more source

Mechanism of Hexane Displaced by Supercritical Carbon Dioxide: Insights from Molecular Simulations

Molecules, 2022
Supercritical carbon dioxide (sCO2) has great potential for displacing shale oil as a result of its high solubility and low surface tension and viscosity, but the underlying mechanisms have remained unclear up to now.
Jiasheng Song, Zhuangying Zhu, Lang Liu
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Numerical research of biodiesel spray coupled cavitation by different environmental simulations under high injection pressure

Energy Science & Engineering, 2023
The effects of injection pressure and ambient pressure on biodiesel spray characteristics were studied by coupling the in‐nozzle flow, and a constant‐volume combustion bomb experimental platform was built to verify the accuracy of the coupled numerical ...
Zhijiang Ni, Guoqing Zhang, Xuefei Zhang, Chaohui Zhou, Yuxing Dai   +4 more
doaj   +1 more source