Results 41 to 50 of about 1,138,447 (216)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Near Wellbore Hydraulic Fracture Propagation from Perforations in Tight Rocks: The Roles of Fracturing Fluid Viscosity and Injection Rate

Energies, 2017
Hydraulic fracture initiation and near wellbore propagation is governed by complex failure mechanisms, especially in cased perforated wellbores. Various parameters affect such mechanisms, including fracturing fluid viscosity and injection rate.
Seyed Hassan Fallahzadeh, Md Mofazzal Hossain, Ashton James Cornwell, Vamegh Rasouli   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A Study of Spill Control Characteristics of JP-8 and Conventional Diesel Fuel with a Common Rail Direct Injection System

Energies, 2017
Diversification of energy sources is a key task for decreasing environmental impacts and global emission of gases. JP-8, a fuel derived from natural gas, coal, biomass, and waste plastics, is a bright prospect.
Seomoon Yang, Hoonyoung Moon, Changhee Lee   +2 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Understanding rate effects in injection-induced earthquakes

Nature Communications, 2020
Understanding the physical mechanisms that underpin the link between fluid injection and seismicity is essential in efforts to mitigate the seismic risk associated with subsurface technologies.
Maryam Alghannam, Ruben Juanes
doaj   +1 more source

Optimal Injection Parameters for Enhancing Coalbed Methane Recovery: A Simulation Study from the Shizhuang Block, Qinshui Basin, China

Geofluids, 2022
The injection of N2 into coal reservoir has great potential in improving recovery of coalbed methane (CBM). In this study, a numerical model was established based on the GEM component model to evaluate the influences of different N2 injection parameters (
Du Liu, Longyong Shu, Yanbin Wang, Zhonggang Huo, Shihu Zhao, Xing Xiong   +5 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Technology and application of controlling injection rate and increasing imbibition effect to enhance oil recovery in fractured sandstone reservoirs with ultra-low permeability： A case study of Ordos Basin

Youqi dizhi yu caishoulu
The pore-throat of the fractured sandstone reservoir matrix with ultra-low permeability is fine， and micro fractures are developed， which provides favorable conditions for the role of imbibition and oil displacement； surfactant solution can change the ...
WANG Xiangzeng, WANG Xiaofeng, LIANG Quansheng, DANG Hailong, HOU Binchi, CUI Pengxing, GAO Tao   +6 more
doaj   +1 more source

Numerical Investigation of Influence of In-Situ Stress Ratio, Injection Rate and Fluid Viscosity on Hydraulic Fracture Propagation Using a Distinct Element Approach

Energies, 2016
Numerical simulation is very useful for understanding the hydraulic fracturing mechanism. In this paper, we simulate the hydraulic fracturing using the distinct element approach, to investigate the effect of some critical parameters on hydraulic ...
Bo Zhang, Xiao Li, Zhaobin Zhang, Yanfang Wu, Yusong Wu, Yu Wang   +5 more
doaj   +1 more source