Results 51 to 60 of about 1,099,154 (258)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

An Analysis on the Effects of the Fuel Injection Rate Shape of the Diesel Spray Mixing Process Using a Numerical Simulation

Applied Sciences, 2020
In diesel engines, fuel mixing is an important process in determining the combustion efficiency and emissions level. One of the measures used to achieve fuel mixing is controlling the nature and behavior of the fuel spray by shaping the injection rate ...
Intarat Naruemon, Long Liu, Dai Liu, Xiuzhen Ma, Keiya Nishida   +4 more
doaj   +1 more source

Injection of Chemicals Into Irrigation Systems: Rates, Volumes, and Injection Periods

EDIS, 1998
Irrigation systems play a crucial role in delivering soluble chemicals to crops through a process known as chemigation. This method allows for precise application of chemicals to either the root zone or aerial parts of plants, or both. Specialized equipment is required for chemigation, with various injection methods available.
Gary A. Clark, Dorota Z. Haman, F. S. Zazueta   +2 more
openaire   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

On the Robustness of Rating Aggregators Against Injection Attacks

, 2020
For a decade now, Academia has been researching refined techniques to detect fake reviews. In this article, rather than proposing a new detection methodology, we propose to contain the consequences of an attack launched by a fake reviewer who attaches arbitrary scores to the review target.
Spognardi Angelo, Petrocchi Marinella
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Combustion and Emission Characteristics of a Diesel Engine with a Variable Injection Rate

Applied Sciences
Diesel engine combustion is dependent mainly on the fuel injection characteristics, particularly the injection pressure and rate, which directly affect the engine efficiency and emissions.
Jun Chen, Guanyu Shi, Jinzhe Wu, Chenghao Cao, Lei Zhou, Wu Xu, Sheng Wang, Xiaofeng Li   +7 more
doaj   +1 more source

Evaluation of miscible and immiscible CO2 injection in one of the Iranian oil fields

Egyptian Journal of Petroleum, 2014
Carbon dioxide (CO2) flooding is one of the most important methods for enhanced oil recovery (EOR) because it not only increases oil recovery efficiency but also causes a reduction of greenhouse gas emissions. It is a very complex system, involving phase
Aref Hashemi Fath, Abdol-Rasoul Pouranfard   +1 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source