Results 71 to 80 of about 1,350,437 (285)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Balancing Efficiency and Emissions: A Study on Biodiesel‐Hydrogen Dual‐Fuel Engine Performance Under Varying Injection Timings

Engineering Reports
The growing demand for cleaner energy sources has intensified research on alternative fuels for diesel engines to mitigate environmental concerns. This study presents a novel approach by investigating the combined effect of injection timing (IT) and ...
Vasanthkumar Periyathambi, Manikandan Ezhumalai, Mohan Govindasamy, Ratchagaraja Dhairiyasamy, Deekshant Varshney, Subhav Singh   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Numerical Study and Optimization of Combustion and Emissions of Ammonia/Diesel Dual-Fuel Engines Under Heavy Load

Energies
Ammonia fuel is expected to emerge as an effective alternative to fossil fuels due to its zero-carbon nature, high-efficiency storage and transportation advantages, and extensive industrial manufacturing infrastructure.
Shikai Xing, Xianglong Li, Juxia Li, Jianbing Gao, Qiang Lu, Xiaochen Wang, Yunge Zhao, Sunchu Wu, Zhonghui Fu   +8 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Influence of CO2 injection timing on enhanced coalbed methane recovery using thermo-hydro-mechanical coupled model

Case Studies in Thermal Engineering
Delayed CO2 injection can prevent premature CO2 breakthrough to production wells during CO2 enhanced coalbed methane (CO2-ECBM) recovery. Currently, the influence of CO2 injection timing on CO2-ECBM recovery is unclear.
Hexiang Xu, Cheng Zhai, Jizhao Xu, Yong Sun, Ting Liu, Yangfeng Zheng, Hongyang Xu, Ting Huang   +7 more
doaj   +1 more source

Implementation of thermal and fuel stratification strategies to extend the load limit of HCCI engine

Journal of Thermal Science and Technology, 2019
The HCCI engine can be a possible potential engine technology that gives high performance with fewer dangerous exhaust emissions. In HCCI engines, low-temperature combustion of lean, highly premixed charge effectively reduces the NOX and soot.
Amit KARWADE, Shashikant THOMBRE
doaj   +1 more source

Injection sites and withdrawal times.

Annales de recherches veterinaires. Annals of veterinary research, 1990
Following parenteral antibiotic administration, various factors influence the persistence of residues at the injection site, for example, the antibiotic itself, the composition of the formulation, the degree of irritation induced and the species of animal medicated.
openaire   +2 more sources