Results 81 to 90 of about 1,350,437 (285)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
A Review of Early Injection Strategy in Premixed Combustion Engines
Applied Sciences, 2019 Due to the increasing awareness of environmental protection, limitations on exhaust emissions of diesel engines have become increasingly stringent. This challenges diesel engine manufacturers to find a new balance between engine performance and emissions.
Xingyu Liang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Diesel engine fuel injection monitoring using acoustic measurements and independent component analysis [PDF]
, 2010 Air-borne acoustic based condition monitoring is a promising technique because of its intrusive nature and the rich information contained within the acoustic signals including all sources.
Gu, Fengshou +7 more
core +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Algorithm based comparison between the integral method and harmonic analysis of the timing jitter of diode-based and solid-state pulsed laser sources [PDF]
, 2015 A comparison between two methods of timing jitter calculation is presented. The integral method utilizes spectral area of the single side-band (SSB) phase noise spectrum to calculate root mean square (rms) timing jitter. In contrast the harmonic analysis
Edwards, T. J. +7 more
core +1 more source
Performance Assessment of a Diesel Engine Fueled with Biodiesel in a Plateau Environment
EnergiesBiodiesel has a higher oxygen content and a higher cetane number, which can compensate for the intake oxygen deficiency in diesel engines in a plateau environment to a certain extent.
Guangmeng Zhou +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Water Injection Effects on the Performance and Emission Characteristics of a CI Engine Operating with Biodiesel [PDF]
, 2012 Biodiesel is one of the most promising renewable, alternative and environmentally friendly biofuels that can be used in diesel engine without any need for any modification in the engine.
Gu, Fengshou +11 more
core +1 more source