Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Experimental Investigation on the Effect of Graphene Oxide in Higher Alcohol Blends and Optimization of Injection Timing Using an ANN Method. [PDF]
ACS Omega, 2023 Natarajan A +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Experimental studies of performance and emissions in a 2/4-stroke engine [PDF]
, 2014 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel UniversityDirect Injection (DI) gasoline engines are staging a come-back because of its potential for improved fuel economy through principally the engine down-sizing
Ojapah, Mohammed
core +4 more sources
Injection parameter optimization for efficient biodiesel blends in compression ignition engine
CT&F Ciencia, Tecnología & FuturoThe increasing global energy demand, depletion of petroleum reserves, volatile petroleum prices, and growing environmental concerns have accelerated the search for sustainable and clean energy sources. Biodiesel (methyl ester) was produced from scum oil (
Harish Hanumanthappa +4 more
doaj +1 more source
The Impact of Corticosteroid Injection Timing on Infection Rates Following Spine Surgery: A Systematic Review and Meta-Analysis. [PDF]
Global Spine J, 2022 Kazarian GS, Steinhaus ME, Kim HJ.
europepmc +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Optimization of biodiesel powered CI engine process parameters using AHP and Taguchi grey method A
Journal of Thermal EngineeringBlends of algae oil with diesel can act as a substitute for diesel are expected to provide organized efficiency and better emission characteristics by controlling the parameters of the compression ignition engine.
Krishnamoorthy NATARAJAN +3 more
doaj +1 more source
Influence of fuel injection timing and trade-off study on the RCCI engine characteristics of Jatropha oil-diesel blend under 1-pentanol dual-fuel strategies. [PDF]
Environ Sci Pollut Res Int, 2023 Ashok A +3 more
europepmc +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source