Results 51 to 60 of about 34,484 (292)

Bioprinting Organs—Science or Fiction?—A Review From Students to Students

Advanced Healthcare Materials, EarlyView.
Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu, Camilla Mussoni, Mateo S. Andrade Mier, Paula Buettner, Nathaly Chicaiza‐Cabezas, Yi‐Yu Robin Dai, Jessica Faber, Maren Fiedler, Zan Lamberger, Xuen Jen Ng, Vanessa Moessler, Anna Rederer, Jonas Roeder, Sabrina Stecher, Katinka Theis, Jeanette Weigelt, Silvia Budday, Gregor Lang, Natascha Schaefer   +18 more
wiley   +1 more source

Effect of repeated intra-articular administration of collagen as a treatment for knee osteoarthritis: a case report

Journal of International Medical Research
Intra-articular injections aimed at correcting underlying pathophysiological processes and providing pain relief are essential for managing knee osteoarthritis (KOA). Collagen, the primary component of articular cartilage, has a long half-life, making it
Yong In, Saad Mohammed Alshammari, Man Soo Kim   +2 more
doaj   +1 more source

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source

Do steroid injections help with osteoarthritis of the knee? [PDF]

, 2004
Intra-articular steroid injections appear to provide 2 to 6 weeks of pain relief for patients with knee osteoarthritis (strength of recommendation [SOR]: A). Higher-dose steroids with or without joint lavage can provide pain relief up to 24 weeks (SOR: A)
Jones, Wanwisa Y., Mayo, Helen G., Palacios, Luis C.   +2 more
core  

Use of bone plates and screws to manage chronic mandibular dislocation [PDF]

, 2010
Different treatment modalities are described in literature to treat mandibular recurrent dislocation, including intra- capsular esclerosant injections, articular eminence reduction, soft tissues suture to limit condilar movement, and grafts or implants ...
Rodrigues Azenha, Marcelo
core   +1 more source

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

Current status and future directions of botulinum neurotoxins for targeting pain processing. [PDF]

, 2015
Current evidence suggests that botulinum neurotoxins (BoNTs) A1 and B1, given locally into peripheral tissues such as skin, muscles, and joints, alter nociceptive processing otherwise initiated by inflammation or nerve injury in animal models and humans.
Pellett, Sabine, Ramachandran, Roshni, Yaksh, Tony L   +2 more
core   +2 more sources

A Photothermal Transducer Regulates Transmembrane Calcium Flow for Synergistic Osteoarthritis Therapy

Advanced Science, EarlyView.
Upon NIR irradiation at 808 nm, the activity of TRPV4 was inhibited by M2M@BPSC, which led to reduced calcium influx, mitochondrial protection, and, importantly, the transcriptional activation of the STAT6‐EGR2 pathway. The improved macrophage function indirectly readjusts the equilibrium between C‐ECM and F‐ECM to reconstruct a suitable ...
Chenqi Yu, Yang Liu, Kang Kang, Jianfeng Yu, Xiaowei Xia, Yaoge Deng, Yingjie Lu, Huilin Yang, Lisong Li, Wu Xu, Yijian Zhang, Xuesong Zhu   +11 more
wiley   +1 more source

Provision of foot health services for people with rheumatoid arthritis in New South Wales: a web-based survey of local podiatrists [PDF]

, 2013
Background: It is unclear if podiatric foot care for people with rheumatoid arthritis (RA) in New South Wales (NSW) meets current clinical recommendations. The objective of this study was to survey podiatrists' perceptions of the nature of podiatric foot
A Blake, A Williams, AC Redmond, AE Williams, AE Williams, AE Williams, AF Marsman, Arthritis and Musculoskeletal Alliance, AS Graham, CJ Bowen, CM Sofka, DE Turner, DE Turner, GJ Hendry, GJ Hendry, Gordon J Hendry, J Firth, J Michelson, J Woodburn, Joshua Burns, JS Smolen, K Hennessy, K Rome, K Rome, Kathryn A Gibson, Keith Rome, Kevin Pile, KL Manfreda, Luke Taylor, M van der Leeden, M van der Leeden, MA D'Agostino, MR Backhouse, National Collaborating Centre for Chronic Conditions, O Wilson, P Helliwell, Podiatry Rheumatic Care Association, R Luqmani, RJ Wakefield, SIG Network, SM Bergin, The Royal College of General Practitioners, Verona du Toit, W Fan   +43 more
core   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source