Results 191 to 200 of about 92,511 (276)

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Benefits of Steroid Injections into Paraspinous Muscles After Spinal Surgery in a Rat Paraspinal Muscle Retraction Model. [PDF]

Int J Mol Sci
Sheu ML, Pan LY, Sheehan J, Lai DW, Chou YC, Pan LY, Wang CC, Chen YJ, Su HL, Tsou HK, Pan HC.   +10 more
europepmc   +1 more source

Nasal Delivery of mRNA Using Thermoresponsive Gellable Aqueous Biphasic Systems

Small, EarlyView.
Nasal delivery of mRNA using gellable aqueous biphasic systems (ABS) represents a noninvasive alternative while reducing the need for trained professionals and cold chain storage. Composed of gelatin, PEG, and water, these thermoresponsive hydrogels ensure controlled mRNA delivery and prolonged retention at the nasal mucosa, improving transfection ...
Bojan Kopilovic, Nabila Laroui, João A.P. Coutinho, Chantal Pichon, Mara G. Freire   +4 more
wiley   +1 more source

Bilateral Nicolau Syndrome Following Intramuscular Gentamicin Injections

JEADV Clinical Practice
Konstantina Kotsia, Louise Gueissaz, Roland Blum, Luca Borradori   +3 more
doaj   +1 more source

Exploring the Interaction Between Injection Site and Biological Sex on the Real-world Population Pharmacokinetics of Long-acting Cabotegravir and Rilpivirine in People With HIV. [PDF]

Open Forum Infect Dis
Tan B, John M, Castley A, Williams L, Joyce D, Nolan D, O'Halloran S, Salman S.   +7 more
europepmc   +1 more source

Precision mRNA Delivery via Ultrasound‐Controlled Release Perfluorocarbon Emulsions: An Innovative Ultrasound Theranostic Strategy with 19F MRI Feasibility

Small, EarlyView.
A key challenge in advancing messenger RNA (mRNA) therapeutics in cardiovascular diseases lies in achieving controlled release at the precise site within the vasculature. This study presents the development of perfluorocarbon nanodroplets with exceptional theranostic potential, enabling real‐time tracking through ultrasound and fluorine‐19 (19F ...
Haikun Liu, Mark Louis P. Vidallon, Yuyang Song, Aidan P. G. Walsh, Henry Gordon, Shulei Ren, Pengkai Shi, Bangyan Xu, Mitchell J. Moon, Sylvain Trépout, Rico F. Tabor, Alexis I. Bishop, Ulrich Flögel, Karlheinz Peter, Xiaowei Wang   +14 more
wiley   +1 more source

Intra- and Postoperative Botulinum Toxin Injection in Postsurgical Pain Management: A Literature Review. [PDF]

Pain Res Manag
Alikarami S, Hosseindoost S, Dehpour AR, Rezaei Z, Majedi H.   +4 more
europepmc   +1 more source

An Integrated Method to Evaluate the Treatment Efficacy and Immunogenicity of B‐Cell Acute Lymphoblastic Leukemia Therapeutic Enzyme Formulations

Small Methods, EarlyView.
This work presents an integrated set of methods to evaluate the efficacy of asparaginase formulations against B‐cell Acute Lymphoblastic Leukemia (ALL) in mice, including the establishment of an ALL murine model, an amino acid depletion study using high‐performance liquid chromatography (HPLC), and comprehensive assessment of antibody production ...
Julien Santelli, Annie Y. Heble, Connor Endsley, Adam Woodward, Nazia Hafeez, Naomi Winick, Jacques Lux   +6 more
wiley   +1 more source

Impact of pre-existing anti-replicase immunity on the efficacy of self-amplifying mRNA vaccines. [PDF]

Nat Commun
Cui X, Amelinck L, Gillon O, Catani JPP, Gao Y, Sun Q, De Sutter E, Vervaeke P, Snoeck J, Lienenklaus S, Saelens X, Zhong Z, Sanders NN.   +12 more
europepmc   +1 more source

Pioneering Device by UNH Faculty Could Give Student Nurses a Shot in the Arm [PDF]

, 2011
Potier, Beth
core   +1 more source